MeSH Browser

MeSH Heading: Insulin-Like Growth Factor Binding Protein 1
Tree Number(s): D12.776.157.420.250
Unique ID: D018970
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D018970
Scope Note: One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)
Entry Term(s): IGF-Binding Protein 1; IGFBP-1
Previous Indexing: Carrier Proteins (1992-1995)
Public MeSH Note: 2005; see INSULIN-LIKE-GROWTH-FACTOR-BINDING PROTEIN-1 1996-2005; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1 was indexed under CARRIER PROTEINS 1992-95
History Note: 2005(1992)
Date Established: 1996/01/01
Date of Entry: 1995/06/08
Revision Date: 2013/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0028341
Scope Note: One of the six homologous proteins that specifically bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions. The function of this protein is not completely defined. However, several studies demonstrate that it inhibits IGF binding to cell surface receptors and thereby inhibits IGF-mediated mitogenic and cell metabolic actions. (Proc Soc Exp Biol Med 1993;204(1):4-29)
Terms: Insulin-Like Growth Factor Binding Protein 1 Preferred Term
Term UI T056567
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1996); IGF-Binding Protein 1
Term UI T056568
Date12/08/1994
LexicalTag NON
ThesaurusID NLM (1996); IGFBP-1
Term UI T056566
Date12/08/1994
LexicalTag ABB
ThesaurusID NLM (1996)

Insulin-Like Growth Factor Binding Protein 1 MeSH Descriptor Data 2025