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Buthionine Sulfoximine MeSH Descriptor Data 2023


MeSH Heading
Buthionine Sulfoximine
Tree Number(s)
D02.886.030.676.620.125
D12.125.166.676.620.125
Unique ID
D019328
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019328
Scope Note
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
Pharm Action
Antimetabolites
Antimetabolites, Antineoplastic
Enzyme Inhibitors
Radiation-Protective Agents
Radiation-Sensitizing Agents
Registry Number
5072-26-4
CAS Type 1 Name
Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-
Previous Indexing
Methionine Sulfoximine (1979-1996)
Public MeSH Note
97; BUTHIONINE SULFOXIMINE was indexed under METHIONINE SULFOXIMINE 1979-96
Online Note
use BUTHIONINE SULFOXIMINE (NM) to search BUTHIONINE SULFOXIMINE 1980-96
History Note
97: was BUTHIONINE SULFOXIMINE (NM) 1979-96
Date Established
1997/01/01
Date of Entry
1996/06/10
Revision Date
2005/06/30
Buthionine Sulfoximine Preferred
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