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Simvastatin MeSH Descriptor Data 2022


MeSH Heading
Simvastatin
Tree Number(s)
D02.455.426.559.847.638.400.900
D04.615.638.400.900
Unique ID
D019821
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D019821
Scope Note
A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
Entry Term(s)
MK-733
Synvinolin
Zocor
Pharm Action
Anticholesteremic Agents
Hypolipidemic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Registry Number
AGG2FN16EV
Related Numbers
79902-63-9
Previous Indexing
Lovastatin/analogs & derivatives (1988-1997)
Naphthalenes (1986-1987)
See Also
Rosuvastatin Calcium
Public MeSH Note
98; SIMVASTATIN was indexed under LOVASTATIN/analogs & derivatives 1988-97 & NAPHTHALENES 1986-87
History Note
98; use SIMVASTATIN (NM) 1986-97
Date Established
1998/01/01
Date of Entry
1997/06/20
Revision Date
2017/01/17
Simvastatin Preferred
Zocor Narrower
MK-733 Narrower
Synvinolin Narrower
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