MeSH Browser

MeSH Heading: Gangliosidoses, GM2
Tree Number(s): C10.228.140.163.100.435.825.300.300; C16.320.565.189.435.825.300.300; C16.320.565.398.641.803.350.300; C16.320.565.595.554.825.300.300; C18.452.132.100.435.825.300.300; C18.452.584.563.641.803.350.300; C18.452.648.189.435.825.300.300; C18.452.648.398.641.803.350.300; C18.452.648.595.554.825.300.300
Unique ID: D020143
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020143
Scope Note: A group of recessively inherited diseases characterized by the intralysosomal accumulation of G(M2) GANGLIOSIDE in the neuronal cells. Subtypes include mutations of enzymes in the BETA-N-ACETYLHEXOSAMINIDASES system or G(M2) ACTIVATOR PROTEIN leading to disruption of normal degradation of GANGLIOSIDES, a subclass of ACIDIC GLYCOSPHINGOLIPIDS.
Entry Term(s): G(M2) Gangliosidoses; GM2 Gangliosidosis; Gangliosidoses GM2
Previous Indexing: Sandhoff Disease (1966-1999); Tay-Sachs Disease (1966-1999)
See Also: beta-N-Acetylhexosaminidases
Public MeSH Note: 2007; see GANGLIOSIDOSES GM2 2000-2006
History Note: 2007 (2000)
Date Established: 2000/01/01
Date of Entry: 1999/11/08
Revision Date: 2021/07/01

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Nervous System Diseases [C10]
- Central Nervous System Diseases [C10.228]
  - Brain Diseases [C10.228.140]
    - Brain Diseases, Metabolic [C10.228.140.163]
      - Brain Diseases, Metabolic, Inborn [C10.228.140.163.100]
        
        Lysosomal Storage Diseases, Nervous System [C10.228.140.163.100.435]
        
        Sphingolipidoses [C10.228.140.163.100.435.825]
        
        Gangliosidoses [C10.228.140.163.100.435.825.300]
        
        Gangliosidoses, GM2 [C10.228.140.163.100.435.825.300.300]
        
        Sandhoff Disease [C10.228.140.163.100.435.825.300.300.249]
        
        Tay-Sachs Disease [C10.228.140.163.100.435.825.300.300.500]
        
        Tay-Sachs Disease, AB Variant [C10.228.140.163.100.435.825.300.300.750]
        
        Gangliosidosis, GM1 [C10.228.140.163.100.435.825.300.400]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Metabolism, Inborn Errors [C16.320.565]
    - Brain Diseases, Metabolic, Inborn [C16.320.565.189]
      - Lysosomal Storage Diseases, Nervous System [C16.320.565.189.435]
        
        Sphingolipidoses [C16.320.565.189.435.825]
        
        Gangliosidoses [C16.320.565.189.435.825.300]
        
        Gangliosidoses, GM2 [C16.320.565.189.435.825.300.300]
        
        Sandhoff Disease [C16.320.565.189.435.825.300.300.249]
        
        Tay-Sachs Disease [C16.320.565.189.435.825.300.300.500]
        
        Tay-Sachs Disease, AB Variant [C16.320.565.189.435.825.300.300.750]
        
        Gangliosidosis, GM1 [C16.320.565.189.435.825.300.400]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Metabolism, Inborn Errors [C16.320.565]
    - Lipid Metabolism, Inborn Errors [C16.320.565.398]
      - Lipidoses [C16.320.565.398.641]
        
        Sphingolipidoses [C16.320.565.398.641.803]
        
        Gangliosidoses [C16.320.565.398.641.803.350]
        
        Gangliosidoses, GM2 [C16.320.565.398.641.803.350.300]
        
        Sandhoff Disease [C16.320.565.398.641.803.350.300.700]
        
        Tay-Sachs Disease [C16.320.565.398.641.803.350.300.850]
        
        Tay-Sachs Disease, AB Variant [C16.320.565.398.641.803.350.300.925]
        
        Gangliosidosis, GM1 [C16.320.565.398.641.803.350.360]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Metabolism, Inborn Errors [C16.320.565]
    - Lysosomal Storage Diseases [C16.320.565.595]
      - Lysosomal Storage Diseases, Nervous System [C16.320.565.595.554]
        
        Sphingolipidoses [C16.320.565.595.554.825]
        
        Gangliosidoses [C16.320.565.595.554.825.300]
        
        Gangliosidoses, GM2 [C16.320.565.595.554.825.300.300]
        
        Sandhoff Disease [C16.320.565.595.554.825.300.300.800]
        
        Tay-Sachs Disease [C16.320.565.595.554.825.300.300.840]
        
        Tay-Sachs Disease, AB Variant [C16.320.565.595.554.825.300.300.920]
        
        Gangliosidosis, GM1 [C16.320.565.595.554.825.300.400]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Brain Diseases, Metabolic [C18.452.132]
    - Brain Diseases, Metabolic, Inborn [C18.452.132.100]
      - Lysosomal Storage Diseases, Nervous System [C18.452.132.100.435]
        
        Sphingolipidoses [C18.452.132.100.435.825]
        
        Gangliosidoses [C18.452.132.100.435.825.300]
        
        Gangliosidoses, GM2 [C18.452.132.100.435.825.300.300]
        
        Sandhoff Disease [C18.452.132.100.435.825.300.300.249]
        
        Tay-Sachs Disease [C18.452.132.100.435.825.300.300.500]
        
        Tay-Sachs Disease, AB Variant [C18.452.132.100.435.825.300.300.750]
        
        Gangliosidosis, GM1 [C18.452.132.100.435.825.300.400]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Lipid Metabolism Disorders [C18.452.584]
    - Lipid Metabolism, Inborn Errors [C18.452.584.563]
      - Lipidoses [C18.452.584.563.641]
        
        Sphingolipidoses [C18.452.584.563.641.803]
        
        Gangliosidoses [C18.452.584.563.641.803.350]
        
        Gangliosidoses, GM2 [C18.452.584.563.641.803.350.300]
        
        Sandhoff Disease [C18.452.584.563.641.803.350.300.700]
        
        Tay-Sachs Disease [C18.452.584.563.641.803.350.300.850]
        
        Tay-Sachs Disease, AB Variant [C18.452.584.563.641.803.350.300.925]
        
        Gangliosidosis, GM1 [C18.452.584.563.641.803.350.360]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Metabolism, Inborn Errors [C18.452.648]
    - Brain Diseases, Metabolic, Inborn [C18.452.648.189]
      - Lysosomal Storage Diseases, Nervous System [C18.452.648.189.435]
        
        Sphingolipidoses [C18.452.648.189.435.825]
        
        Gangliosidoses [C18.452.648.189.435.825.300]
        
        Gangliosidoses, GM2 [C18.452.648.189.435.825.300.300]
        
        Sandhoff Disease [C18.452.648.189.435.825.300.300.249]
        
        Tay-Sachs Disease [C18.452.648.189.435.825.300.300.500]
        
        Tay-Sachs Disease, AB Variant [C18.452.648.189.435.825.300.300.750]
        
        Gangliosidosis, GM1 [C18.452.648.189.435.825.300.400]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Metabolism, Inborn Errors [C18.452.648]
    - Lipid Metabolism, Inborn Errors [C18.452.648.398]
      - Lipidoses [C18.452.648.398.641]
        
        Sphingolipidoses [C18.452.648.398.641.803]
        
        Gangliosidoses [C18.452.648.398.641.803.350]
        
        Gangliosidoses, GM2 [C18.452.648.398.641.803.350.300]
        
        Sandhoff Disease [C18.452.648.398.641.803.350.300.700]
        
        Tay-Sachs Disease [C18.452.648.398.641.803.350.300.850]
        
        Tay-Sachs Disease, AB Variant [C18.452.648.398.641.803.350.300.925]
        
        Gangliosidosis, GM1 [C18.452.648.398.641.803.350.360]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - Metabolism, Inborn Errors [C18.452.648]
    - Lysosomal Storage Diseases [C18.452.648.595]
      - Lysosomal Storage Diseases, Nervous System [C18.452.648.595.554]
        
        Sphingolipidoses [C18.452.648.595.554.825]
        
        Gangliosidoses [C18.452.648.595.554.825.300]
        
        Gangliosidoses, GM2 [C18.452.648.595.554.825.300.300]
        
        Sandhoff Disease [C18.452.648.595.554.825.300.300.800]
        
        Tay-Sachs Disease [C18.452.648.595.554.825.300.300.840]
        
        Tay-Sachs Disease, AB Variant [C18.452.648.595.554.825.300.300.920]
        
        Gangliosidosis, GM1 [C18.452.648.595.554.825.300.400]

Gangliosidoses, GM2 Preferred

Concept UI: M0328040
Scope Note: A group of recessively inherited diseases characterized by the intralysosomal accumulation of G(M2) GANGLIOSIDE in the neuronal cells. Subtypes include mutations of enzymes in the BETA-N-ACETYLHEXOSAMINIDASES system or G(M2) ACTIVATOR PROTEIN leading to disruption of normal degradation of GANGLIOSIDES, a subclass of ACIDIC GLYCOSPHINGOLIPIDS.
Terms: Gangliosidoses, GM2 Preferred Term
Term UI T647014
Date07/27/2005
LexicalTag NON
ThesaurusID NLM (2007); GM2 Gangliosidosis
Term UI T368291
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); Gangliosidoses GM2
Term UI T358040
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); G(M2) Gangliosidoses
Term UI T368285
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000)

Gangliosidoses, GM2 MeSH Descriptor Data 2023