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Gangliosidoses, GM2 MeSH Descriptor Data 2022


MeSH Heading
Gangliosidoses, GM2
Tree Number(s)
C10.228.140.163.100.435.825.300.300
C16.320.565.189.435.825.300.300
C16.320.565.398.641.803.350.300
C16.320.565.595.554.825.300.300
C18.452.132.100.435.825.300.300
C18.452.584.563.641.803.350.300
C18.452.648.189.435.825.300.300
C18.452.648.398.641.803.350.300
C18.452.648.595.554.825.300.300
Unique ID
D020143
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D020143
Scope Note
A group of recessively inherited diseases characterized by the intralysosomal accumulation of G(M2) GANGLIOSIDE in the neuronal cells. Subtypes include mutations of enzymes in the BETA-N-ACETYLHEXOSAMINIDASES system or G(M2) ACTIVATOR PROTEIN leading to disruption of normal degradation of GANGLIOSIDES, a subclass of ACIDIC GLYCOSPHINGOLIPIDS.
Entry Term(s)
G(M2) Gangliosidoses
GM2 Gangliosidosis
Gangliosidoses GM2
Previous Indexing
Sandhoff Disease (1966-1999)
Tay-Sachs Disease (1966-1999)
See Also
beta-N-Acetylhexosaminidases
Public MeSH Note
2007; see GANGLIOSIDOSES GM2 2000-2006
History Note
2007 (2000)
Date Established
2000/01/01
Date of Entry
1999/11/08
Revision Date
2021/07/01
Gangliosidoses, GM2 Preferred
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