MeSH Browser

MeSH Heading: ATP Binding Cassette Transporter, Subfamily B, Member 1
Tree Number(s): D12.776.157.530.100.075.063; D12.776.157.530.450.074.500.500.250.125; D12.776.395.550.020.400.153; D12.776.543.550.192.400.153; D12.776.543.585.100.200.125; D12.776.543.585.450.074.500.500.250.125
Unique ID: D020168
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020168
Annotation: note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B is also available
Scope Note: A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
Entry Term(s): ABCB1 Protein; ATP Binding Cassette Transporter, Sub-Family B, Member 1; ATP-Binding Cassette, Sub-Family B, Member 1; CD243 Antigen; MDR1 Protein; Multidrug Resistance Protein 1; P-Glycoprotein; PGY-1 Protein
Registry Number: 0
Previous Indexing: P-Glycoprotein (1995-1998)
See Also: Drug Resistance, Multiple
Public MeSH Note: 2019; see ATP-BINDING CASSETTE, SUB-FAMILY B, MEMBER 1 2018; see P-GLYCOPROTEIN 1995-2017; ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B, MEMBER 1 was indexed under P-GLYCOPROTEIN 1995-1998; under CARRIER PROTEINS & MEMBRANE GLYCOPROTEINS 1980-1994; under GLYCOPROTEINS 1980-1987; and under MEMBRANE PROTEINS 1980-1982
History Note: 2019 (1995)
Date Established: 1999/01/01
Date of Entry: 1998/07/20
Revision Date: 2018/07/13

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - ATP-Binding Cassette Transporters [D12.776.157.530.100]
        
        ATP Binding Cassette Transporter, Subfamily B [D12.776.157.530.100.075]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 1 [D12.776.157.530.100.075.063]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 11 [D12.776.157.530.100.075.125]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 2 [D12.776.157.530.100.075.250]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 3 [D12.776.157.530.100.075.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Pumps [D12.776.157.530.450]
        
        Anion Transport Proteins [D12.776.157.530.450.074]
        
        Organic Anion Transporters [D12.776.157.530.450.074.500]
        
        Organic Anion Transporters, ATP-Dependent [D12.776.157.530.450.074.500.500]
        
        ATP Binding Cassette Transporter, Subfamily B [D12.776.157.530.450.074.500.500.250]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 1 [D12.776.157.530.450.074.500.500.250.125]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 2 [D12.776.157.530.450.074.500.500.250.250]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 3 [D12.776.157.530.450.074.500.500.250.375]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 11 [D12.776.157.530.450.074.500.500.250.438]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - ATP-Binding Cassette Transporters [D12.776.395.550.020]
        
        ATP Binding Cassette Transporter, Subfamily B [D12.776.395.550.020.400]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 1 [D12.776.395.550.020.400.153]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 2 [D12.776.395.550.020.400.305]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 3 [D12.776.395.550.020.400.458]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 11 [D12.776.395.550.020.400.534]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - ATP-Binding Cassette Transporters [D12.776.543.550.192]
        
        ATP Binding Cassette Transporter, Subfamily B [D12.776.543.550.192.400]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 1 [D12.776.543.550.192.400.153]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 2 [D12.776.543.550.192.400.305]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 3 [D12.776.543.550.192.400.458]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 11 [D12.776.543.550.192.400.534]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - ATP-Binding Cassette Transporters [D12.776.543.585.100]
        
        ATP Binding Cassette Transporter, Subfamily B [D12.776.543.585.100.200]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 1 [D12.776.543.585.100.200.125]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 2 [D12.776.543.585.100.200.250]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 3 [D12.776.543.585.100.200.375]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 11 [D12.776.543.585.100.200.438]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Pumps [D12.776.543.585.450]
        
        Anion Transport Proteins [D12.776.543.585.450.074]
        
        Organic Anion Transporters [D12.776.543.585.450.074.500]
        
        Organic Anion Transporters, ATP-Dependent [D12.776.543.585.450.074.500.500]
        
        ATP Binding Cassette Transporter, Subfamily B [D12.776.543.585.450.074.500.500.250]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 1 [D12.776.543.585.450.074.500.500.250.125]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 2 [D12.776.543.585.450.074.500.500.250.250]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 3 [D12.776.543.585.450.074.500.500.250.375]
        
        ATP Binding Cassette Transporter, Subfamily B, Member 11 [D12.776.543.585.450.074.500.500.250.438]

ATP Binding Cassette Transporter, Subfamily B, Member 1 Preferred

Concept UI: M0029890
Registry Number: 0
Scope Note: A 170-kDa transmembrane glycoprotein from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS. It serves as an ATP-dependent efflux pump for a variety of chemicals, including many ANTINEOPLASTIC AGENTS. Overexpression of this glycoprotein is associated with multidrug resistance (see DRUG RESISTANCE, MULTIPLE).
Terms: ATP Binding Cassette Transporter, Subfamily B, Member 1 Preferred Term
Term UI T000938089
Date12/21/2017
LexicalTag ABX
ThesaurusID NLM (2019); CD243 Antigen
Term UI T000892229
Date12/17/2015
LexicalTag NON
ThesaurusID NLM (2017); ATP Binding Cassette Transporter, Sub-Family B, Member 1
Term UI T000935791
Date11/08/2017
LexicalTag ABX
ThesaurusID NLM (2019); PGY-1 Protein
Term UI T443684
Date04/20/2001
LexicalTag NON
ThesaurusID NLM (2002); MDR1 Protein
Term UI T059962
Date01/16/1998
LexicalTag NON
ThesaurusID NLM (1999); Multidrug Resistance Protein 1
Term UI T439157
Date03/14/2001
LexicalTag NON
ThesaurusID NLM (2002); ATP-Binding Cassette, Sub-Family B, Member 1
Term UI T442817
Date04/13/2001
LexicalTag ABX
ThesaurusID NLM (2002); ABCB1 Protein
Term UI T000892228
Date12/17/2015
LexicalTag ABX
ThesaurusID NLM (2017); P-Glycoprotein
Term UI T059961
Date01/01/1999
LexicalTag ABX
ThesaurusID NLM (1999)

ATP Binding Cassette Transporter, Subfamily B, Member 1 MeSH Descriptor Data 2023