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ATP Binding Cassette Transporter, Subfamily B MeSH Descriptor Data 2023


MeSH Heading
ATP Binding Cassette Transporter, Subfamily B
Tree Number(s)
D12.776.157.530.100.075
D12.776.157.530.450.074.500.500.250
D12.776.395.550.020.400
D12.776.543.550.192.400
D12.776.543.585.100.200
D12.776.543.585.450.074.500.500.250
Unique ID
D018435
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D018435
Annotation
note entry term: ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 is also available
Scope Note
A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs (especially ANTINEOPLASTIC AGENTS) from cells, causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology.
Entry Term(s)
ATP Binding Cassette Transporter, Sub-Family B
ATP-Binding Cassette, Sub-Family B Proteins
Multidrug Resistance Proteins
P-Glycoproteins
Registry Number
0
Previous Indexing
Glycoproteins (1980-1987)
Membrane Glycoproteins (1989-1994)
Membrane Proteins (1980-1988)
See Also
Drug Resistance, Multiple
Genes, MDR
Multidrug Resistance-Associated Proteins
Rhodamine 123
Public MeSH Note
2019; see ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY B 2018; see P-GLYCOPROTEIN 1995-1998; P-GLYCOPROTEIN was indexed under CARRIER PROTEINS & MEMBRANE GLYCOPROTEINS 1980-1994, GLYCOPROTEINS 1980-1987, and MEMBRANE PROTEINS 1980-1982
History Note
2019 (1999); use P-GLYCOPROTEIN 1995-1998
Date Established
1995/01/01
Date of Entry
1994/01/25
Revision Date
2019/04/29
ATP Binding Cassette Transporter, Subfamily B Preferred
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