ATP Binding Cassette Transporter, Subfamily A MeSH Descriptor Data 2025

MeSH Heading: ATP Binding Cassette Transporter, Subfamily A
Tree Number(s): D09.400.430.890.020.381; D12.776.157.530.100.050; D12.776.395.550.020.381; D12.776.543.550.192.381; D12.776.543.585.100.190
Unique ID: D000073874
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000073874
Scope Note: A large, highly conserved, subfamily of ATP binding cassette transporters structurally characterized by a membrane-spanning domain composed of six ALPHA-HELICES, a large extracellular loop, nucleotide-binding domain, and a conserved cytoplasmic 80 amino acid sequence. In humans, it includes ABCA1(ATP BINDING CASSETTE TRANSPORTER 1) through ABCA10, as well as ABCA12 and ABCA13.
Entry Term(s): ABCA Transporters; ATP Binding Cassette Transporter, Sub-Family A
Previous Indexing: ATP-Binding Cassette Transporters (2001-2017)
Public MeSH Note: 2019; see ATP BINDING CASSETTE TRANSPORTER, SUB-FAMILY A 2018
History Note: 2019 (2018)
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2023/03/16

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Carbohydrates [D09]
- Glycoconjugates [D09.400]
  - Glycoproteins [D09.400.430]
    - Membrane Glycoproteins [D09.400.430.890]
      - ATP-Binding Cassette Transporters [D09.400.430.890.020]
        
        ATP Binding Cassette Transporter, Subfamily A [D09.400.430.890.020.381]
        
        ATP Binding Cassette Transporter 1 [D09.400.430.890.020.381.500]
        
        ATP Binding Cassette Transporter, Subfamily A, Member 4 [D09.400.430.890.020.381.750]
        
        ATP Binding Cassette Transporter, Subfamily B [D09.400.430.890.020.400]
        
        ATP Binding Cassette Transporter, Subfamily D [D09.400.430.890.020.419]
        
        ATP Binding Cassette Transporter, Subfamily G [D09.400.430.890.020.457]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - ATP-Binding Cassette Transporters [D12.776.157.530.100]
        
        ATP Binding Cassette Transporter, Subfamily A [D12.776.157.530.100.050]
        
        ATP Binding Cassette Transporter 1 [D12.776.157.530.100.050.500]
        
        ATP Binding Cassette Transporter, Subfamily A, Member 4 [D12.776.157.530.100.050.750]
        
        ATP Binding Cassette Transporter, Subfamily B [D12.776.157.530.100.075]
        
        ATP Binding Cassette Transporter, Subfamily D [D12.776.157.530.100.209]
        
        ATP Binding Cassette Transporter, Subfamily G [D12.776.157.530.100.228]
        
        Multidrug Resistance-Associated Proteins [D12.776.157.530.100.304]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Glycoproteins [D12.776.395]
    - Membrane Glycoproteins [D12.776.395.550]
      - ATP-Binding Cassette Transporters [D12.776.395.550.020]
        
        ATP Binding Cassette Transporter, Subfamily A [D12.776.395.550.020.381]
        
        ATP Binding Cassette Transporter 1 [D12.776.395.550.020.381.500]
        
        ATP Binding Cassette Transporter, Subfamily A, Member 4 [D12.776.395.550.020.381.750]
        
        ATP Binding Cassette Transporter, Subfamily B [D12.776.395.550.020.400]
        
        ATP Binding Cassette Transporter, Subfamily D [D12.776.395.550.020.419]
        
        ATP Binding Cassette Transporter, Subfamily G [D12.776.395.550.020.457]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - ATP-Binding Cassette Transporters [D12.776.543.550.192]
        
        ATP Binding Cassette Transporter, Subfamily A [D12.776.543.550.192.381]
        
        ATP Binding Cassette Transporter 1 [D12.776.543.550.192.381.500]
        
        ATP Binding Cassette Transporter, Subfamily A, Member 4 [D12.776.543.550.192.381.750]
        
        ATP Binding Cassette Transporter, Subfamily B [D12.776.543.550.192.400]
        
        ATP Binding Cassette Transporter, Subfamily D [D12.776.543.550.192.419]
        
        ATP Binding Cassette Transporter, Subfamily G [D12.776.543.550.192.457]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - ATP-Binding Cassette Transporters [D12.776.543.585.100]
        
        ATP Binding Cassette Transporter, Subfamily A [D12.776.543.585.100.190]
        
        ATP Binding Cassette Transporter 1 [D12.776.543.585.100.190.500]
        
        ATP Binding Cassette Transporter, Subfamily A, Member 4 [D12.776.543.585.100.190.750]
        
        ATP Binding Cassette Transporter, Subfamily B [D12.776.543.585.100.200]
        
        ATP Binding Cassette Transporter, Subfamily D [D12.776.543.585.100.209]
        
        ATP Binding Cassette Transporter, Subfamily G [D12.776.543.585.100.228]
        
        Multidrug Resistance-Associated Proteins [D12.776.543.585.100.304]
        
        Sulfonylurea Receptors [D12.776.543.585.100.805]

ATP Binding Cassette Transporter, Subfamily A Preferred

Concept UI: M000624144
Scope Note: A large, highly conserved, subfamily of ATP binding cassette transporters structurally characterized by a membrane-spanning domain composed of six ALPHA-HELICES, a large extracellular loop, nucleotide-binding domain, and a conserved cytoplasmic 80 amino acid sequence. In humans, it includes ABCA1(ATP BINDING CASSETTE TRANSPORTER 1) through ABCA10, as well as ABCA12 and ABCA13.
Terms: ATP Binding Cassette Transporter, Subfamily A Preferred Term
Term UI T000939215
Date01/16/2018
LexicalTag NON
ThesaurusID NLM (2019); ATP Binding Cassette Transporter, Sub-Family A
Term UI T000912314
Date11/29/2016
LexicalTag ABX
ThesaurusID NLM (2018); ABCA Transporters
Term UI T000912315
Date11/29/2016
LexicalTag ABX
ThesaurusID NLM (2018)

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