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Multidrug Resistance-Associated Proteins MeSH Descriptor Data 2022


MeSH Heading
Multidrug Resistance-Associated Proteins
Tree Number(s)
D12.776.157.530.100.304
D12.776.157.530.450.074.500.500.500
D12.776.543.585.100.304
D12.776.543.585.450.074.500.500.500
Unique ID
D027425
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D027425
Scope Note
A sequence-related subfamily of ATP-BINDING CASSETTE TRANSPORTERS that actively transport organic substrates. Although considered organic anion transporters, a subset of proteins in this family have also been shown to convey drug resistance to neutral organic drugs. Their cellular function may have clinical significance for CHEMOTHERAPY in that they transport a variety of ANTINEOPLASTIC AGENTS. Overexpression of proteins in this class by NEOPLASMS is considered a possible mechanism in the development of multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although similar in function to P-GLYCOPROTEINS, the proteins in this class share little sequence homology to the ATP BINDING CASSETTE TRANSPORTER, SUBFAMILY B, MEMBER 1 family of proteins.
Entry Version
MULTIDRUG RESISTANCE ASSOC PROTEINS
Entry Term(s)
ATP-Binding Cassette, Sub-Family C Proteins
MOAT Protein
Multidrug Resistance-Associated Protein
Multispecific Organic Anion Transport Proteins
Multispecific Organic Anion Transporter
Registry Number
0
Previous Indexing
P-Glycoprotein (1987-2001)
See Also
ATP Binding Cassette Transporter, Subfamily B
Drug Resistance, Multiple
Public MeSH Note
2002; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN was indexed under ABC TRANSPORTERS 1994-2001; MOAT PROTEIN & MULTISPECIFIC ORGANIC ANION TRANSPORTER were indexed under CARRIER PROTEINS 1995-2001
History Note
2002; use MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS (NM) 1994-2001; for MOAT PROTEIN & MULTISPECIFIC ORGANIC ANION TRANSPORTER use ANION TRANSPORT PROTEINS 1995-2001
Date Established
2002/01/01
Date of Entry
2001/07/25
Revision Date
2018/07/13
Multidrug Resistance-Associated Proteins Preferred
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