MeSH Browser

MeSH Heading: Cleavage And Polyadenylation Specificity Factor
Tree Number(s): D12.776.157.725.124.240; D12.776.664.962.444.240
Unique ID: D039223
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D039223
Scope Note: An RNA-binding protein that recognizes the AAU‌AAA RNA SEQUENCE at the 3' end of MRNA. It contains four subunits of 30, 73, 100 and 160 kDa molecular size and combines with CLEAVAGE STIMULATION FACTOR to form a stable complex with mRNA that directs the 3' cleavage and polyadenylation reaction.
Entry Term(s): CPSF 30K; CPSF Protein; CPSF-100-kDa Subunit; CPSF-160-kDa Subunit; CPSF-30-kDa Subunit; CPSF-73-kDa Subunit; Cleavage And Polyadenylation Specificity Factor, 100-kDa Subunit; Cleavage And Polyadenylation Specificity Factor, 160-kDa Subunit; Cleavage And Polyadenylation Specificity Factor, 30-kDa Subunit; Cleavage And Polyadenylation Specificity Factor, 73-kDa Subunit; Cleavage-Polyadenylation Specificity Factor
Previous Indexing: RNA-Binding Proteins (1992-2002)
Public MeSH Note: 2003; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR was indexed under RNA-BINDING PROTEINS 1992-2002
History Note: 2003; for CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR use MRNA CLEAVAGE AND POLYADENYLATION FACTORS (NM) 1992-2002
Date Established: 2003/01/01
Date of Entry: 2002/07/03
Revision Date: 2006/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Cleavage And Polyadenylation Specificity Factor MeSH Descriptor Data 2025