MeSH Browser

MeSH Heading: Vascular Endothelial Growth Factor A
Tree Number(s): D12.644.276.100.800.200; D12.776.467.100.800.200; D23.529.100.800.200
Unique ID: D042461
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D042461
Scope Note: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as tumor angiogenesis factor and vascular permeability factor. Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Entry Term(s): GD-VEGF; Glioma-Derived Vascular Endothelial Cell Growth Factor; VEGF; VEGF-A; Vascular Endothelial Growth Factor; Vascular Endothelial Growth Factor-A; Vascular Permeability Factor; Vasculotropin
Previous Indexing: Endothelial Growth Factors (2000-2003)
Public MeSH Note: 2004; VASCULAR ENDOTHELIAL GROWTH FACTOR was indexed under ENDOTHELIAL GROWTH FACTORS 2000-2002
History Note: 2004; use VASCULAR ENDOTHELIAL GROWTH FACTOR A (NM) 2000-2002
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2013/07/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intercellular Signaling Peptides and Proteins [D12.644.276]
    - Angiogenic Proteins [D12.644.276.100]
      - Vascular Endothelial Growth Factors [D12.644.276.100.800]
        
        Placenta Growth Factor [D12.644.276.100.800.100]
        
        Vascular Endothelial Growth Factor A [D12.644.276.100.800.200]
        
        Vascular Endothelial Growth Factor B [D12.644.276.100.800.300]
        
        Vascular Endothelial Growth Factor C [D12.644.276.100.800.400]
        
        Vascular Endothelial Growth Factor D [D12.644.276.100.800.500]
        
        Vascular Endothelial Growth Factor, Endocrine-Gland-Derived [D12.644.276.100.800.600]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intercellular Signaling Peptides and Proteins [D12.776.467]
    - Angiogenic Proteins [D12.776.467.100]
      - Vascular Endothelial Growth Factors [D12.776.467.100.800]
        
        Vascular Endothelial Growth Factor A [D12.776.467.100.800.200]
        
        Vascular Endothelial Growth Factor B [D12.776.467.100.800.300]
        
        Vascular Endothelial Growth Factor C [D12.776.467.100.800.400]
        
        Vascular Endothelial Growth Factor D [D12.776.467.100.800.500]
        
        Vascular Endothelial Growth Factor, Endocrine-Gland-Derived [D12.776.467.100.800.600]

Biological Factors [D23]
- Intercellular Signaling Peptides and Proteins [D23.529]
  - Angiogenic Proteins [D23.529.100]
    - Vascular Endothelial Growth Factors [D23.529.100.800]

Vascular Endothelial Growth Factor A Preferred

Concept UI: M0356369
Scope Note: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as tumor angiogenesis factor and vascular permeability factor. Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Terms: Vascular Endothelial Growth Factor A Preferred Term
Term UI T406107
Date01/31/2000
LexicalTag NON
ThesaurusID NLM (2004); Vascular Endothelial Growth Factor
Term UI T087222
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Vascular Endothelial Growth Factor-A
Term UI T526412
Date11/20/2002
LexicalTag NON
ThesaurusID NLM (2004); Vascular Permeability Factor
Term UI T087224
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); Vasculotropin
Term UI T207077
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2004); VEGF
Term UI T087210
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2004); VEGF-A
Term UI T406108
Date01/31/2000
LexicalTag ACR
ThesaurusID NLM (2004)

Glioma-Derived Vascular Endothelial Cell Growth Factor Narrower

Vascular Endothelial Growth Factor A MeSH Descriptor Data 2025