An angiogenic protein belonging to the Vascular Endothelial Growth Factor family of growth factors originally isolated and cloned from human placental cDNA library. There are four isoforms of PLGF 1-4 which result from alternative splicing. Placenta Growth Factor is secreted as a glycosylated homodimer which acts as a mitogen for endothelial cells, and its expression is markedly upregulated during hypoxia and in tissue inflammation and cancer.
Entry Term(s)
Placenta Growth Factor, PLGF-1 Isoform
Placenta Growth Factor, PLGF-2 Isoform
Placenta Growth Factor, PLGF-3 Isoform
Placenta Growth Factor, PLGF-4 Isoform
Registry Number
144589-93-5
Public MeSH Note
2017; PLACENTA GROWTH FACTOR was indexed under PREGNANCY PROTEINS 1991-2016
An angiogenic protein belonging to the Vascular Endothelial Growth Factor family of growth factors originally isolated and cloned from human placental cDNA library. There are four isoforms of PLGF 1-4 which result from alternative splicing. Placenta Growth Factor is secreted as a glycosylated homodimer which acts as a mitogen for endothelial cells, and its expression is markedly upregulated during hypoxia and in tissue inflammation and cancer.
