MeSH Browser

MeSH Heading: Estrogenic Steroids, Alkylated
Tree Number(s): D06.472.334.851.437.968
Unique ID: D042782
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D042782
Scope Note: Estrogenic STEROIDS with aliphatic hydrocarbon chain substitution on C17 or other position. 17-alpha-ALKYLATION renders the molecule more stable, resistant to metabolic degradation, and improves oral efficacy. Examples of synthetic alkyl estrogens include ETHINYL ESTRADIOL and MESTRANOL. Substitutions at other sites generates antiestrogenic and cytotoxic properties.
Entry Term(s): Alkyl Estrogenic Steroids; Alkylated Estrogenic Steroids
Pharm Action: Estrogens
Previous Indexing: Ethinyl Estradiol (1968-2003)
Public MeSH Note: 2004
History Note: 2004
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 1955/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0441916
Scope Note: Estrogenic STEROIDS with aliphatic hydrocarbon chain substitution on C17 or other position. 17-alpha-ALKYLATION renders the molecule more stable, resistant to metabolic degradation, and improves oral efficacy. Examples of synthetic alkyl estrogens include ETHINYL ESTRADIOL and MESTRANOL. Substitutions at other sites generates antiestrogenic and cytotoxic properties.
Terms: Estrogenic Steroids, Alkylated Preferred Term
Term UI T525984
Date11/13/2002
LexicalTag NON
ThesaurusID NLM (2004); Alkyl Estrogenic Steroids
Term UI T525985
Date11/13/2002
LexicalTag NON
ThesaurusID NLM (2004); Alkylated Estrogenic Steroids
Term UI T542700
Date06/09/2003
LexicalTag NON
ThesaurusID NLM (2004)

Estrogenic Steroids, Alkylated MeSH Descriptor Data 2025