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Chromosome Fragile Sites MeSH Descriptor Data 2023

MeSH Heading
Chromosome Fragile Sites
Tree Number(s)
Unique ID
RDF Unique Identifier
Scope Note
Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)
Entry Term(s)
Fragile Sites, Chromosome
Previous Indexing
Chromosome Fragility (1982-2003)
See Also
Chromosome Fragility
DNA Repeat Expansion
Fragile X Syndrome
Public MeSH Note
2004; see CHROMOSOME FRAGILITY 1982-2003
History Note
2004; use CHROMOSOME FRAGILITY 1982-2003
Date Established
Date of Entry
Revision Date
Chromosome Fragile Sites Preferred
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