MeSH Browser

MeSH Heading: Mitogen-Activated Protein Kinase 8
Tree Number(s): D08.811.913.696.620.682.700.567.374.500; D12.776.476.563.567.374.500
Unique ID: D048055
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D048055
Scope Note: A c-jun amino-terminal kinase that is activated by environmental stress and pro-inflammatory cytokines. Several isoforms of the protein with molecular sizes of 43 and 48 KD exist due to multiple ALTERNATIVE SPLICING.
Entry Term(s): JNK1 Kinase; MAPK8 Mitogen-Activated Protein Kinase; SAP Kinase-1; SAPK1 Mitogen-Activated Protein Kinase; Stress-Activated Protein Kinase 1; Stress-Activated Protein Kinase JNK1; Stress-Activated Protein Kinase gamma; c-jun Kinase-1; c-jun N-Terminal Kinase 1
Registry Number: EC 2.7.11.24
Previous Indexing: Mitogen-Activated Protein Kinases (2000-2004)
Public MeSH Note: 2005; MITOGEN-ACTIVATED PROTEIN KINASE 8 was indexed under MITOGEN-ACTIVATED PROTEIN KINASES 2000-2004
History Note: 2005(2000)
Date Established: 2005/01/01
Date of Entry: 2004/07/07
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567]
        
        JNK Mitogen-Activated Protein Kinases [D08.811.913.696.620.682.700.567.374]
        
        Mitogen-Activated Protein Kinase 8 [D08.811.913.696.620.682.700.567.374.500]
        
        Mitogen-Activated Protein Kinase 9 [D08.811.913.696.620.682.700.567.374.750]
        
        Mitogen-Activated Protein Kinase 10 [D08.811.913.696.620.682.700.567.374.800]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]
      - Mitogen-Activated Protein Kinases [D12.776.476.563.567]
        
        JNK Mitogen-Activated Protein Kinases [D12.776.476.563.567.374]
        
        Mitogen-Activated Protein Kinase 8 [D12.776.476.563.567.374.500]
        
        Mitogen-Activated Protein Kinase 9 [D12.776.476.563.567.374.750]
        
        Mitogen-Activated Protein Kinase 10 [D12.776.476.563.567.374.800]

Mitogen-Activated Protein Kinase 8 Preferred

Concept UI: M0362611
Registry Number: EC 2.7.11.24
Scope Note: A c-jun amino-terminal kinase that is activated by environmental stress and pro-inflammatory cytokines. Several isoforms of the protein with molecular sizes of 43 and 48 KD exist due to multiple ALTERNATIVE SPLICING.
Terms: Mitogen-Activated Protein Kinase 8 Preferred Term
Term UI T571728
Date02/06/2004
LexicalTag NON
ThesaurusID NLM (2005); c-jun Kinase-1
Term UI T423287
Date09/06/2000
LexicalTag ACX
ThesaurusID NLM (2005); SAP Kinase-1
Term UI T423290
Date09/06/2000
LexicalTag ACX
ThesaurusID NLM (2005); Stress-Activated Protein Kinase gamma
Term UI T572997
Date02/17/2004
LexicalTag NON
ThesaurusID NLM (2005); c-jun N-Terminal Kinase 1
Term UI T571730
Date02/06/2004
LexicalTag ACX
ThesaurusID NLM (2005); MAPK8 Mitogen-Activated Protein Kinase
Term UI T572994
Date02/17/2004
LexicalTag ACX
ThesaurusID NLM (2005); JNK1 Kinase
Term UI T572995
Date02/17/2004
LexicalTag ACX
ThesaurusID NLM (2005); SAPK1 Mitogen-Activated Protein Kinase
Term UI T572996
Date02/17/2004
LexicalTag ACX
ThesaurusID NLM (2005); Stress-Activated Protein Kinase 1
Term UI T414589
Date05/17/2000
LexicalTag NON
ThesaurusID NLM (2005); Stress-Activated Protein Kinase JNK1
Term UI T571729
Date02/06/2004
LexicalTag ACX
ThesaurusID NLM (2005)

Mitogen-Activated Protein Kinase 8 MeSH Descriptor Data 2023