MAP Kinase Kinase 5 MeSH Descriptor Data 2025

MeSH Heading: MAP Kinase Kinase 5
Tree Number(s): D08.811.913.696.620.682.700.565.500; D08.811.913.696.620.682.725.200.500; D12.776.476.563.565.500; D12.776.476.568.200.500
Unique ID: D048671
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D048671
Scope Note: A mitogen-activated protein kinase kinase with specificity for MITOGEN-ACTIVATED PROTEIN KINASE 7.
Entry Term(s): MAP2K5 Protein; MAPK-ERK Kinase 5; MAPKK-5 Protein Kinase; MAPKK5 Protein Kinase; Mitogen-Activated Protein Kinase Kinase 5
Registry Numbers: EC 2.7.12.2
Previous Indexing: Mitogen-Activated Protein Kinases (2000-2004); Protein-Serine-Threonine Kinases (1995-1999); Protein-Tyrosine Kinase (1995-1999)
Public MeSH Note: 2005; MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 was indexed under MITOGEN-ACTIVATED PROTEIN KINASES 2000-2004, & under PROTEIN-TYROSINE KINASE & PROTEIN-SERINE-THREONINE KINASES 1995-1999
History Note: 2005(1995)
Date Established: 2005/01/01
Date of Entry: 2004/07/07
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein Serine-Threonine Kinases [D08.811.913.696.620.682.700]
        
        Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.700.565]
        
        MAP Kinase Kinase 1 [D08.811.913.696.620.682.700.565.100]
        
        MAP Kinase Kinase 2 [D08.811.913.696.620.682.700.565.200]
        
        MAP Kinase Kinase 3 [D08.811.913.696.620.682.700.565.300]
        
        MAP Kinase Kinase 4 [D08.811.913.696.620.682.700.565.400]
        
        MAP Kinase Kinase 5 [D08.811.913.696.620.682.700.565.500]
        
        MAP Kinase Kinase 6 [D08.811.913.696.620.682.700.565.600]
        
        MAP Kinase Kinase 7 [D08.811.913.696.620.682.700.565.700]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Protein Kinases [D08.811.913.696.620.682]
        
        Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
        
        Mitogen-Activated Protein Kinase Kinases [D08.811.913.696.620.682.725.200]
        
        MAP Kinase Kinase 1 [D08.811.913.696.620.682.725.200.100]
        
        MAP Kinase Kinase 2 [D08.811.913.696.620.682.725.200.200]
        
        MAP Kinase Kinase 3 [D08.811.913.696.620.682.725.200.300]
        
        MAP Kinase Kinase 4 [D08.811.913.696.620.682.725.200.400]
        
        MAP Kinase Kinase 5 [D08.811.913.696.620.682.725.200.500]
        
        MAP Kinase Kinase 6 [D08.811.913.696.620.682.725.200.600]
        
        MAP Kinase Kinase 7 [D08.811.913.696.620.682.725.200.700]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein Serine-Threonine Kinases [D12.776.476.563]
      - Mitogen-Activated Protein Kinase Kinases [D12.776.476.563.565]
        
        MAP Kinase Kinase 1 [D12.776.476.563.565.100]
        
        MAP Kinase Kinase 2 [D12.776.476.563.565.200]
        
        MAP Kinase Kinase 3 [D12.776.476.563.565.300]
        
        MAP Kinase Kinase 4 [D12.776.476.563.565.400]
        
        MAP Kinase Kinase 5 [D12.776.476.563.565.500]
        
        MAP Kinase Kinase 6 [D12.776.476.563.565.600]
        
        MAP Kinase Kinase 7 [D12.776.476.563.565.700]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Protein-Tyrosine Kinases [D12.776.476.568]
      - Mitogen-Activated Protein Kinase Kinases [D12.776.476.568.200]
        
        MAP Kinase Kinase 1 [D12.776.476.568.200.100]
        
        MAP Kinase Kinase 2 [D12.776.476.568.200.200]
        
        MAP Kinase Kinase 3 [D12.776.476.568.200.300]
        
        MAP Kinase Kinase 4 [D12.776.476.568.200.400]
        
        MAP Kinase Kinase 5 [D12.776.476.568.200.500]
        
        MAP Kinase Kinase 6 [D12.776.476.568.200.600]
        
        MAP Kinase Kinase 7 [D12.776.476.568.200.700]

MAP Kinase Kinase 5 Preferred

Concept UI: M0247117
Registry Numbers: EC 2.7.12.2
Scope Note: A mitogen-activated protein kinase kinase with specificity for MITOGEN-ACTIVATED PROTEIN KINASE 7.
Terms: MAP Kinase Kinase 5 Preferred Term
Term UI T367411
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2005); MAPK-ERK Kinase 5
Term UI T277121
Date01/01/1955
LexicalTag ACX
ThesaurusID NLM (2005); Mitogen-Activated Protein Kinase Kinase 5
Term UI T571946
Date02/09/2004
LexicalTag NON
ThesaurusID NLM (2005); MAPKK5 Protein Kinase
Term UI T576683
Date03/12/2004
LexicalTag ACX
ThesaurusID NLM (2005); MAP2K5 Protein
Term UI T581322
Date04/06/2004
LexicalTag ACX
ThesaurusID NLM (2005); MAPKK-5 Protein Kinase
Term UI T581323
Date04/06/2004
LexicalTag ACX
ThesaurusID NLM (2005)

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