MeSH Browser

MeSH Heading: G(M2) Activator Protein
Tree Number(s): D08.211.790.249
Unique ID: D049289
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D049289
Scope Note: An essential cofactor for the degradation of G(M2)GANGLIOSIDE by lysosomal BETA-N-ACETYLHEXOSAMINIDASES. Genetic mutations resulting in loss of G(M2) activator protein are one of the causes of TAY-SACHS DISEASE, AB VARIANT.
Entry Term(s): GM(2) Activating Protein; GM2 Activator Protein; Hexosaminidase Activator
Previous Indexing: Proteins (1983-2004)
Public MeSH Note: 2005; G(M2) ACTIVATOR PROTEIN was indexed under PROTEINS 1983-2004
History Note: 2005(1983)
Date Established: 2005/01/01
Date of Entry: 2004/07/08
Revision Date: 2007/07/11

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0111676
Scope Note: An essential cofactor for the degradation of G(M2)GANGLIOSIDE by lysosomal BETA-N-ACETYLHEXOSAMINIDASES. Genetic mutations resulting in loss of G(M2) activator protein are one of the causes of TAY-SACHS DISEASE, AB VARIANT.
Terms: G(M2) Activator Protein Preferred Term
Term UI T141676
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); GM(2) Activating Protein
Term UI T141677
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); GM2 Activator Protein
Term UI T141678
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); Hexosaminidase Activator
Term UI T141679
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005)

G(M2) Activator Protein MeSH Descriptor Data 2025