MeSH Browser

MeSH Heading: Succinate-Semialdehyde Dehydrogenase
Tree Number(s): D08.811.682.657.163.843
Unique ID: D050644
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050644
Scope Note: An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA).
Entry Term(s): NAD(+)-Dependent Succinic Semialdehyde Dehydrogenase; Succinate Semialdehyde Dehydrogenase; Succinic Semialdehyde Dehydrogenase
Registry Number: EC 1.2.1.24
Related Numbers: 9028-95-9
Public MeSH Note: 2006; SUCCINATE-SEMIALDEHYDE DEHYDROGENASE was indexed under ALDEHYDE OXIDOREDUCTASES 1977-2005
History Note: 2006(1980); use ALDEHYDE OXIDREDUCTASES 1977-1979
Date Established: 2006/01/01
Date of Entry: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0079133
Registry Number: EC 1.2.1.24
Related Numbers: 9028-95-9
Scope Note: An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA).
Terms: Succinate-Semialdehyde Dehydrogenase Preferred Term
Term UI T109136
LexicalTag NON
ThesaurusID NLM (2006); Succinate Semialdehyde Dehydrogenase
Term UI T502747
Date07/03/2002
LexicalTag NON
ThesaurusID NLM (2006); Succinic Semialdehyde Dehydrogenase
Term UI T109135
LexicalTag NON
ThesaurusID NLM (2006); NAD(+)-Dependent Succinic Semialdehyde Dehydrogenase
Term UI T621823
Date12/05/2004
LexicalTag ABX
ThesaurusID NLM (2006)

Succinate-Semialdehyde Dehydrogenase MeSH Descriptor Data 2023