MeSH Browser

MeSH Heading: Methylmalonate-Semialdehyde Dehydrogenase (Acylating)
Tree Number(s): D08.811.682.657.163.827
Unique ID: D050646
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D050646
Scope Note: An enzyme that plays a role in the VALINE; LEUCINE; and ISOLEUCINE catabolic pathways by catalyzing the oxidation of 2-methyl-3-oxopropanate to propanoyl-CoA using NAD+ as a coenzyme. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated BETA-ALANINE and 3-hydropropionic acid.
Entry Term(s): MMSA Dehydrogenase; MMSDH; Methylmalonic-Semialdehyde Dehydrogenase (Acylating)
Public MeSH Note: 2006; METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE (ACYLATING) was indexed under ALDEHYDE OXIDOREDUCTASES 1987-2005
History Note: 2006(1987)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2009/07/15

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0144948
Scope Note: An enzyme that plays a role in the VALINE; LEUCINE; and ISOLEUCINE catabolic pathways by catalyzing the oxidation of 2-methyl-3-oxopropanate to propanoyl-CoA using NAD+ as a coenzyme. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated BETA-ALANINE and 3-hydropropionic acid.
Terms: Methylmalonate-Semialdehyde Dehydrogenase (Acylating) Preferred Term
Term UI T174953
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); MMSDH
Term UI T174949
Date01/01/1955
LexicalTag ACR
ThesaurusID NLM (2006); Methylmalonic-Semialdehyde Dehydrogenase (Acylating)
Term UI T174950
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); MMSA Dehydrogenase
Term UI T174948
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2006)

Methylmalonate-Semialdehyde Dehydrogenase (Acylating) MeSH Descriptor Data 2025