Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Methylmalonate-Semialdehyde Dehydrogenase (Acylating) MeSH Descriptor Data 2026


MeSH Heading
Methylmalonate-Semialdehyde Dehydrogenase (Acylating)
Tree Number(s)
D08.811.682.657.163.827
Unique ID
D050646
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D050646
Scope Note
An enzyme that plays a role in the VALINE; LEUCINE; and ISOLEUCINE catabolic pathways by catalyzing the oxidation of 2-methyl-3-oxopropanate to propanoyl-CoA using NAD+ as a coenzyme. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated BETA-ALANINE and 3-hydropropionic acid.
Entry Term(s)
MMSA Dehydrogenase
MMSDH
Methylmalonic-Semialdehyde Dehydrogenase (Acylating)
Registry Numbers
EC 1.2.1.27
Public MeSH Note
2006; METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE (ACYLATING) was indexed under ALDEHYDE OXIDOREDUCTASES 1987-2005
History Note
2006(1987)
Date Introduced
2006/01/01
Last Updated
2009/07/15
Methylmalonate-Semialdehyde Dehydrogenase (Acylating) Preferred
page delivered in 0.129s