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Methylmalonate-Semialdehyde Dehydrogenase (Acylating) MeSH Descriptor Data 2022


MeSH Heading
Methylmalonate-Semialdehyde Dehydrogenase (Acylating)
Tree Number(s)
D08.811.682.657.163.827
Unique ID
D050646
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D050646
Scope Note
An enzyme that plays a role in the VALINE; LEUCINE; and ISOLEUCINE catabolic pathways by catalyzing the oxidation of 2-methyl-3-oxopropanate to propanoyl-CoA using NAD+ as a coenzyme. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated BETA-ALANINE and 3-hydropropionic acid.
Entry Term(s)
MMSA Dehydrogenase
MMSDH
Methylmalonic-Semialdehyde Dehydrogenase (Acylating)
Registry Number
EC 1.2.1.27
Public MeSH Note
2006; METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE (ACYLATING) was indexed under ALDEHYDE OXIDOREDUCTASES 1987-2005
History Note
2006(1987)
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2009/07/15
Methylmalonate-Semialdehyde Dehydrogenase (Acylating) Preferred
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