MeSH Browser

MeSH Heading: Chromogranin A
Tree Number(s): D12.776.631.199.249
Unique ID: D053379
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053379
Scope Note: A type of chromogranin which was first isolated from CHROMAFFIN CELLS of the ADRENAL MEDULLA but is also found in other tissues and in many species including human, bovine, rat, mouse, and others. It is an acidic protein with 431 to 445 amino acid residues. It contains fragments that inhibit vasoconstriction or release of hormones and neurotransmitter, while other fragments exert antimicrobial actions.
Entry Term(s): CHGA Protein; Parathyroid Secretory Protein; Secretory Protein I, Parathyroid Gland
Previous Indexing: Adrenal Medulla (1968-2003); Chromogranins (1973-2006)
Public MeSH Note: 2007; CHROMOGRANIN A was indexed under CHROMOGRANINS 1981-2006
History Note: 2007 (1981)
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2016/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0492852
Scope Note: A type of chromogranin which was first isolated from CHROMAFFIN CELLS of the ADRENAL MEDULLA but is also found in other tissues and in many species including human, bovine, rat, mouse, and others. It is an acidic protein with 431 to 445 amino acid residues. It contains fragments that inhibit vasoconstriction or release of hormones and neurotransmitter, while other fragments exert antimicrobial actions.
Terms: Chromogranin A Preferred Term
Term UI T125476
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); CHGA Protein
Term UI T000896315
Date03/02/2016
LexicalTag ABX
ThesaurusID NLM (2017); Secretory Protein I, Parathyroid Gland
Term UI T101132
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007); Parathyroid Secretory Protein
Term UI T101133
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2007)

Chromogranin A MeSH Descriptor Data 2025