Keratin-16 MeSH Descriptor Data 2025

MeSH Heading: Keratin-16
Tree Number(s): D05.750.078.593.450.300.600; D12.776.220.475.450.300.600; D12.776.860.607.300.600
Unique ID: D053536
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053536
Scope Note: A type I keratin expressed in a variety of EPITHELIUM, including the ESOPHAGUS, the TONGUE, the HAIR FOLLICLE and NAILS. Keratin-16 is normally found associated with KERATIN-6. Mutations in the gene for keratin-6 have been associated with PACHYONYCHIA CONGENITA, TYPE 1.
Entry Term(s): Cytokeratin 16; Cytokeratin-16
Previous Indexing: Keratins (1998-2006)
Public MeSH Note: 2007; for CYTOKERATIN 16 see KERATIN 1998-2006
History Note: 2007(1998)
Entry Combination: deficiency:Pachyonychia Congenita
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 1955/01/01

Entry Combination: deficiency:Pachyonychia Congenita
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Macromolecular Substances [D05]
- Polymers [D05.750]
  - Biopolymers [D05.750.078]
    - Intermediate Filament Proteins [D05.750.078.593]
      - Keratins [D05.750.078.593.450]
        
        Keratins, Type I [D05.750.078.593.450.300]
        
        Keratin-10 [D05.750.078.593.450.300.100]
        
        Keratin-12 [D05.750.078.593.450.300.200]
        
        Keratin-13 [D05.750.078.593.450.300.300]
        
        Keratin-14 [D05.750.078.593.450.300.400]
        
        Keratin-16 [D05.750.078.593.450.300.600]
        
        Keratin-17 [D05.750.078.593.450.300.700]
        
        Keratin-18 [D05.750.078.593.450.300.800]
        
        Keratin-19 [D05.750.078.593.450.300.900]
        
        Keratin-20 [D05.750.078.593.450.300.950]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Cytoskeletal Proteins [D12.776.220]
    - Intermediate Filament Proteins [D12.776.220.475]
      - Keratins [D12.776.220.475.450]
        
        Keratins, Type I [D12.776.220.475.450.300]
        
        Keratin-10 [D12.776.220.475.450.300.100]
        
        Keratin-12 [D12.776.220.475.450.300.200]
        
        Keratin-13 [D12.776.220.475.450.300.300]
        
        Keratin-14 [D12.776.220.475.450.300.400]
        
        Keratin-15 [D12.776.220.475.450.300.500]
        
        Keratin-16 [D12.776.220.475.450.300.600]
        
        Keratin-17 [D12.776.220.475.450.300.700]
        
        Keratin-18 [D12.776.220.475.450.300.800]
        
        Keratin-19 [D12.776.220.475.450.300.900]
        
        Keratin-20 [D12.776.220.475.450.300.950]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Scleroproteins [D12.776.860]
    - Keratins [D12.776.860.607]
      - Keratins, Type I [D12.776.860.607.300]
        
        Keratin-10 [D12.776.860.607.300.100]
        
        Keratin-12 [D12.776.860.607.300.200]
        
        Keratin-13 [D12.776.860.607.300.300]
        
        Keratin-14 [D12.776.860.607.300.400]
        
        Keratin-16 [D12.776.860.607.300.600]
        
        Keratin-17 [D12.776.860.607.300.700]
        
        Keratin-18 [D12.776.860.607.300.800]
        
        Keratin-19 [D12.776.860.607.300.900]
        
        Keratin-20 [D12.776.860.607.300.950]

Keratin-16 Preferred

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