MeSH Browser

MeSH Heading: Receptor, Interferon alpha-beta
Tree Number(s): D12.776.543.750.705.852.400.500
Unique ID: D053633
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053633
Scope Note: A ubiquitously expressed heterodimeric receptor that is specific for both INTERFERON-ALPHA and INTERFERON-BETA. It is composed of two subunits referred to as IFNAR1 and IFNAR2. The IFNAR2 subunit is believed to serve as the ligand-binding chain; however both chains are required for signal transduction. The interferon alpha-beta receptor signals through the action of JANUS KINASES such as the TYK2 KINASE.
Entry Term(s): IFN-alphaR; IFN-alphabetaR; IFNAR1 Subunit, Interferon alpha-beta Receptor; IFNAR2 Subunit, Interferon alpha-beta Receptor; IFNAR2.1 Subunit, Interferon alpha-beta Receptor; IFNAR2.2 Subunit, Interferon alpha-beta Receptor; Interferon alpha Receptor; Interferon alpha Receptors; Interferon alpha-beta Receptor; Interferon alpha-beta Receptor Chain 1; Interferon alpha-beta Receptor Chain 2; Interferon alpha-beta Receptor IFNAR1 Subunit; Interferon alpha-beta Receptor IFNAR2 Subunit; Interferon alpha-beta Receptor-1; Interferon alpha-beta Receptor-2; Interferon alphabeta Receptors; Receptor, Interferon alpha; Type I Interferon Receptor
Registry Number: 156986-95-7
Public MeSH Note: 2007; INTERFERON ALPHA-BETA RECEPTOR was indexed under MEMBRANE PROTEINS and RECEPTORS, INTERFERON 1994-2006; INTERFERON ALPHA RECEPTOR was indexed under RECEPTORS, INTERFERON 1993-2006
History Note: 2007(1993)
Date Established: 2007/01/01
Date of Entry: 2006/07/05

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Immunologic [D12.776.543.750.705]
        
        Receptors, Cytokine [D12.776.543.750.705.852]
        
        Receptors, Interferon [D12.776.543.750.705.852.400]
        
        Receptor, Interferon alpha-beta [D12.776.543.750.705.852.400.500]

Receptor, Interferon alpha-beta Preferred

Concept UI: M0231011
Registry Number: 156986-95-7
Scope Note: A ubiquitously expressed heterodimeric receptor that is specific for both INTERFERON-ALPHA and INTERFERON-BETA. It is composed of two subunits referred to as IFNAR1 and IFNAR2. The IFNAR2 subunit is believed to serve as the ligand-binding chain; however both chains are required for signal transduction. The interferon alpha-beta receptor signals through the action of JANUS KINASES such as the TYK2 KINASE.
Terms: Receptor, Interferon alpha-beta Preferred Term
Term UI T261013
LexicalTag NON
ThesaurusID NLM (2007); IFN-alphaR
Term UI T253666
LexicalTag ABB
ThesaurusID NLM (2007); Interferon alpha Receptor
Term UI T253669
LexicalTag NON
ThesaurusID NLM (2007); Type I Interferon Receptor
Term UI T261015
LexicalTag NON
ThesaurusID NLM (2007); Interferon alpha-beta Receptor
Term UI T261016
LexicalTag NON
ThesaurusID NLM (2007); Interferon alphabeta Receptors
Term UI T261012
LexicalTag NON
ThesaurusID NLM (2007); Receptor, Interferon alpha
Term UI T253668
LexicalTag NON
ThesaurusID NLM (2007); IFN-alphabetaR
Term UI T261008
LexicalTag ABX
ThesaurusID NLM (2007); Interferon alpha Receptors
Term UI T253667
LexicalTag NON
ThesaurusID NLM (2007)

Interferon alpha-beta Receptor Chain 2 Narrower

Interferon alpha-beta Receptor Chain 1 Narrower

IFNAR2.1 Subunit, Interferon alpha-beta Receptor Narrower

IFNAR2.2 Subunit, Interferon alpha-beta Receptor Narrower

Receptor, Interferon alpha-beta MeSH Descriptor Data 2023