MeSH Browser

MeSH Heading: Dihydropyrimidine Dehydrogenase Deficiency
Tree Number(s): C16.320.565.798.183; C18.452.648.798.183
Unique ID: D054067
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054067
Scope Note: An autosomal recessive disorder affecting DIHYDROPYRIMIDINE DEHYDROGENASE and causing familial pyrimidinemia. It is characterized by thymine-uraciluria in homozygous deficient patients. Even a partial deficiency in the enzyme leaves individuals at risk for developing severe 5-FLUOROURACIL-associated toxicity.
Entry Term(s): DPD Deficiency; Dihydropyrimidinuria; Familial Pyrimidemia; Familial Pyrimidinemia; Hereditary Thymine-Uraciluria; Pyrimidinemia, Familial; Thymine-Uraciluria, Hereditary
Previous Indexing: Dihydrouracil Dehydrogenase (NADP) (1984-2007)
Public MeSH Note: 2008
History Note: 2008
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2013/07/08

Allowable Qualifiers: blood (BL)

cerebrospinal fluid (CF)

chemically induced (CI)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

surgery (SU)

therapy (TH)

urine (UR)

veterinary (VE)

virology (VI)

Concept UI: M0500884
Scope Note: An autosomal recessive disorder affecting DIHYDROPYRIMIDINE DEHYDROGENASE and causing familial pyrimidinemia. It is characterized by thymine-uraciluria in homozygous deficient patients. Even a partial deficiency in the enzyme leaves individuals at risk for developing severe 5-FLUOROURACIL-associated toxicity.
Terms: Dihydropyrimidine Dehydrogenase Deficiency Preferred Term
Term UI T679827
Date08/17/2006
LexicalTag NON
ThesaurusID; Pyrimidinemia, Familial
Term UI T812679
Date11/15/2011
LexicalTag NON
ThesaurusID OMIM (2013); Thymine-Uraciluria, Hereditary
Term UI T679829
Date08/17/2006
LexicalTag NON
ThesaurusID; Familial Pyrimidinemia
Term UI T679828
Date08/17/2006
LexicalTag NON
ThesaurusID; Hereditary Thymine-Uraciluria
Term UI T841274
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014); DPD Deficiency
Term UI T843522
Date05/02/2013
LexicalTag ABX
ThesaurusID GHR (2014); Familial Pyrimidemia
Term UI T841273
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014)

Dihydropyrimidine Dehydrogenase Deficiency MeSH Descriptor Data 2025