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Perforin MeSH Descriptor Data 2023


MeSH Heading
Perforin
Tree Number(s)
D12.776.543.695.875
Unique ID
D054353
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D054353
Scope Note
A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
Entry Term(s)
Cytolysin
Lymphocyte Pore-Forming Protein
Perforin 1
Pharm Action
Cytotoxins
Registry Number
126465-35-8
Previous Indexing
Membrane Glycoproteins (1985-2007)
Pore Forming Cytotoxic Proteins (1985-2007)
Public MeSH Note
2008; PERFORIN was indexed under MEMBRANE GLYCOPROTEINS & PORE FORMING CYTOTOXIC PROTEINS 1985-2007
History Note
2008
Date Established
2008/01/01
Date of Entry
2007/07/09
Revision Date
2008/07/08
Perforin Preferred
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