MeSH Browser

MeSH Heading: Perforin
Tree Number(s): D12.776.543.695.875
Unique ID: D054353
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D054353
Scope Note: A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
Entry Term(s): Cytolysin; Lymphocyte Pore-Forming Protein; Perforin 1
Pharm Action: Cytotoxins
Previous Indexing: Membrane Glycoproteins (1985-2007); Pore Forming Cytotoxic Proteins (1985-2007)
Public MeSH Note: 2008; PERFORIN was indexed under MEMBRANE GLYCOPROTEINS & PORE FORMING CYTOTOXIC PROTEINS 1985-2007
History Note: 2008
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2008/07/08

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0133732
Scope Note: A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
Terms: Perforin Preferred Term
Term UI T163737
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); Perforin 1
Term UI T163733
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2008); Cytolysin
Term UI T602609
Date08/10/2004
LexicalTag NON
ThesaurusID NLM (2008); Lymphocyte Pore-Forming Protein
Term UI T602608
Date08/10/2004
LexicalTag NON
ThesaurusID NLM (2008)

Perforin MeSH Descriptor Data 2025