MeSH Browser

MeSH Heading: Nuclear Receptor Subfamily 1, Group D, Member 1
Tree Number(s): D12.776.260.643.080; D12.776.476.156.300; D12.776.826.209.080
Unique ID: D056953
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D056953
Scope Note: A DNA-binding orphan nuclear receptor that negatively regulates expression of ARNTL TRANSCRIPTION FACTORS and plays a role as a regulatory component of the circadian clock system. The Nr1d1 nuclear receptor expression is cyclically-regulated by a feedback loop involving its positive regulation by CLOCK PROTEIN; BMAL1 PROTEIN heterodimers and its negative regulation by CRYPTOCHROME and PERIOD PROTEINS.
Entry Term(s): Nuclear Receptor NR1D1; Rev-erb-alpha Nuclear Receptors; V-erbA-Related Protein EAR-1
Previous Indexing: DNA-Binding Proteins (1990-2009); Receptors, Cytoplasmic and Nuclear (1990-2009)
Public MeSH Note: 2010
History Note: 2010
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2018/07/02

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0533600
Scope Note: A DNA-binding orphan nuclear receptor that negatively regulates expression of ARNTL TRANSCRIPTION FACTORS and plays a role as a regulatory component of the circadian clock system. The Nr1d1 nuclear receptor expression is cyclically-regulated by a feedback loop involving its positive regulation by CLOCK PROTEIN; BMAL1 PROTEIN heterodimers and its negative regulation by CRYPTOCHROME and PERIOD PROTEINS.
Terms: Nuclear Receptor Subfamily 1, Group D, Member 1 Preferred Term
Term UI T747410
Date03/11/2009
LexicalTag NON
ThesaurusID NLM (2010); Rev-erb-alpha Nuclear Receptors
Term UI T747409
Date03/11/2009
LexicalTag ABX
ThesaurusID NLM (2010); Nuclear Receptor NR1D1
Term UI T750462
Date05/04/2009
LexicalTag ABX
ThesaurusID NLM (2010); V-erbA-Related Protein EAR-1
Term UI T750463
Date05/04/2009
LexicalTag ABX
ThesaurusID NLM (2010)

Nuclear Receptor Subfamily 1, Group D, Member 1 MeSH Descriptor Data 2025