MeSH Browser

MeSH Heading: Class II Phosphatidylinositol 3-Kinases
Tree Number(s): D08.811.913.696.620.500.100.200; D08.811.913.696.620.500.200.200; D12.776.476.556.100.200; D12.776.476.556.200.200
Unique ID: D058541
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D058541
Scope Note: A subclass of phosphatidylinositol 3-kinases that have specificity for 1-phosphatidylinositol and 1-phosphatidylinositol 4-phosphate. Members of this subclass consist of a single subunit structure and are regulated by RECEPTOR TYROSINE KINASES; CYTOKINE RECEPTORS; and INTEGRINS.
Entry Term(s): Phosphatidylinositol 3-Kinase, Class II; Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing alpha Polypeptide; Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing beta Polypeptide; Phosphatidylinositol-4-Phosphate 3-Kinase C2 Domain-Containing gamma Polypeptide; Phosphoinositide 3-Kinase C2alpha; Phosphoinositide 3-Kinase-C2-beta; Phosphoinositide 3-Kinase-C2-gamma; Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide; Phosphoinositide-3-Kinase, Class 2, beta Polypeptide; Phosphoinositide-3-Kinase, Class 2, gamma Polypeptide; Phosphoinositide-3-Kinase, Class II, alpha Polypeptide; Phosphoinositide-3-Kinase, Class II, beta Polypeptide; Phosphoinositide-3-Kinase, Class II, gamma Polypeptide; PtdIns-3-Kinase C2 alpha; PtdIns-3-Kinase C2 beta; PtdIns-3-Kinase C2 gamma
Registry Numbers: EC 2.7.1.137; EC 2.7.1.154; EC 2.7.1.154; EC 2.7.1.154
Related Numbers: EC 2.7.1.154
Previous Indexing: Phosphatidylinositol 3-Kinases (1998-2010)
Public MeSH Note: 2011; PHOSPHOINOSITIDE 3-KINASE C2ALPHA was indexed under PHOSPHATIDYLINOSITOL 3-KINASES 2003-2010
History Note: 2011
Date Established: 2011/01/01
Date of Entry: 2010/06/25
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500]
        
        Phosphatidylinositol 3-Kinase [D08.811.913.696.620.500.100]
        
        Class I Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500.100.100]
        
        Class II Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500.100.200]
        
        Class III Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500.100.300]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500]
        
        Phosphatidylinositol-4-Phosphate 3-Kinase [D08.811.913.696.620.500.200]
        
        Class I Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500.200.100]
        
        Class II Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500.200.200]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Phosphatidylinositol 3-Kinases [D12.776.476.556]
      - Phosphatidylinositol 3-Kinase [D12.776.476.556.100]
        
        Class I Phosphatidylinositol 3-Kinases [D12.776.476.556.100.100]
        
        Class II Phosphatidylinositol 3-Kinases [D12.776.476.556.100.200]
        
        Class III Phosphatidylinositol 3-Kinases [D12.776.476.556.100.300]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Phosphatidylinositol 3-Kinases [D12.776.476.556]
      - Phosphatidylinositol-4-Phosphate 3-Kinase [D12.776.476.556.200]
        
        Class I Phosphatidylinositol 3-Kinases [D12.776.476.556.200.100]
        
        Class II Phosphatidylinositol 3-Kinases [D12.776.476.556.200.200]

Class II Phosphatidylinositol 3-Kinases Preferred

Phosphoinositide-3-Kinase, Class II, alpha Polypeptide Narrower

Phosphoinositide-3-Kinase, Class II, gamma Polypeptide Narrower

Phosphoinositide-3-Kinase, Class II, beta Polypeptide Narrower

Class II Phosphatidylinositol 3-Kinases MeSH Descriptor Data 2025