MeSH Browser

MeSH Heading: Class Ia Phosphatidylinositol 3-Kinase
Tree Number(s): D08.811.913.696.620.500.100.100.100; D08.811.913.696.620.500.200.100.100; D12.776.476.556.100.100.100; D12.776.476.556.200.100.100
Unique ID: D058543
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D058543
Scope Note: A phosphatidylinositol 3-kinase subclass that includes enzymes formed through the heterodimerization of a p110 catalytic and a p85, p55, or p50 regulatory subunit. This subclass of enzymes is a downstream target of TYROSINE KINASE RECEPTORS and G PROTEIN-COUPLED RECEPTORS.
Entry Term(s): Class Ia Phosphatidylinositol 3-Kinase, p110alpha Subunit; Class Ia Phosphatidylinositol 3-Kinase, p110beta Subunit; Class Ia Phosphatidylinositol 3-Kinase, p110delta Subunit; Class Ia Phosphatidylinositol 3-Kinase, p50alpha Subunit; Class Ia Phosphatidylinositol 3-Kinase, p55alpha Subunit; Class Ia Phosphatidylinositol 3-Kinase, p55gamma Subunit; Class Ia Phosphatidylinositol 3-Kinase, p85alpha Subunit; Class Ia Phosphatidylinositol 3-Kinase, p85beta Subunit; Class Ia Phosphatidylinositol 3-Kinases; Class Ia Phosphatidylinositol 3-kinase, Regulatory, alpha Polypeptide; Class Ia Phosphatidylinositol 3-kinase, Regulatory, beta Polypeptide; Class Ia Phosphatidylinositol 3-kinase, Regulatory, gamma Polypeptide; Phosphatidylinositol 3-Kinase, Class Ia; Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide; Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide; Phosphoinositide-3-Kinase, Catalytic, delta Polypeptide; Phosphoinositide-3-Kinase, Regulatory Subunit 1; Phosphoinositide-3-Kinase, Regulatory Subunit 2; Phosphoinositide-3-Kinase, Regulatory Subunit 3; alpha-P85 Subunit, PI-3K; p110alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase; p110beta Subunit, Class Ia Phosphatidylinositol 3-Kinase; p110delta Subunit, Class Ia Phosphatidylinositol 3-Kinase; p50alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase; p55alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase; p55gamma Subunit, Class Ia Phosphatidylinositol 3-Kinase; p85alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase; p85beta Subunit, Class Ia Phosphatidylinositol 3-Kinase
Registry Number: EC 2.7.1.137
Related Numbers: EC 2.7.1.137; EC 2.7.1.154
Previous Indexing: Phosphatidylinositol 3-Kinases (1998-2010)
Public MeSH Note: 2011; for ALPHA-P85 SUBUNIT, PI-3K see PHOSPHATIDYLINOSITOL 3-KINASE 1998-2010
History Note: 2011; for ALPHA-P85 SUBUNIT, PI-3K use PHOSPHATIDYLINOSITOL 3-KINASES 1998-2010
Date Established: 2011/01/01
Date of Entry: 2010/06/25
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500]
        
        Phosphatidylinositol 3-Kinase [D08.811.913.696.620.500.100]
        
        Class I Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500.100.100]
        
        Class Ia Phosphatidylinositol 3-Kinase [D08.811.913.696.620.500.100.100.100]
        
        Class Ib Phosphatidylinositol 3-Kinase [D08.811.913.696.620.500.100.100.200]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Transferases [D08.811.913]
    - Phosphotransferases [D08.811.913.696]
      - Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
        
        Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500]
        
        Phosphatidylinositol-4-Phosphate 3-Kinase [D08.811.913.696.620.500.200]
        
        Class I Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500.200.100]
        
        Class Ia Phosphatidylinositol 3-Kinase [D08.811.913.696.620.500.200.100.100]
        
        Class Ib Phosphatidylinositol 3-Kinase [D08.811.913.696.620.500.200.100.200]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Phosphatidylinositol 3-Kinases [D12.776.476.556]
      - Phosphatidylinositol 3-Kinase [D12.776.476.556.100]
        
        Class I Phosphatidylinositol 3-Kinases [D12.776.476.556.100.100]
        
        Class Ia Phosphatidylinositol 3-Kinase [D12.776.476.556.100.100.100]
        
        Class Ib Phosphatidylinositol 3-Kinase [D12.776.476.556.100.100.200]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Phosphatidylinositol 3-Kinases [D12.776.476.556]
      - Phosphatidylinositol-4-Phosphate 3-Kinase [D12.776.476.556.200]
        
        Class I Phosphatidylinositol 3-Kinases [D12.776.476.556.200.100]
        
        Class Ia Phosphatidylinositol 3-Kinase [D12.776.476.556.200.100.100]
        
        Class Ib Phosphatidylinositol 3-Kinase [D12.776.476.556.200.100.200]

Class Ia Phosphatidylinositol 3-Kinase Preferred

Concept UI: M0543148
Registry Number: EC 2.7.1.137
Related Numbers: EC 2.7.1.137; EC 2.7.1.154
Scope Note: A phosphatidylinositol 3-kinase subclass that includes enzymes formed through the heterodimerization of a p110 catalytic and a p85, p55, or p50 regulatory subunit. This subclass of enzymes is a downstream target of TYROSINE KINASE RECEPTORS and G PROTEIN-COUPLED RECEPTORS.
Terms: Class Ia Phosphatidylinositol 3-Kinase Preferred Term
Term UI T764938
Date01/28/2010
LexicalTag NON
ThesaurusID NLM (2011); Class Ia Phosphatidylinositol 3-Kinases
Term UI T764936
Date01/28/2010
LexicalTag NON
ThesaurusID NLM (2011); Phosphatidylinositol 3-Kinase, Class Ia
Term UI T764937
Date01/28/2010
LexicalTag NON
ThesaurusID NLM (2011)

Class Ia Phosphatidylinositol 3-Kinase, p110beta Subunit Narrower

Class Ia Phosphatidylinositol 3-Kinase, p110delta Subunit Narrower

Class Ia Phosphatidylinositol 3-Kinase, p85beta Subunit Narrower

Class Ia Phosphatidylinositol 3-Kinase, p55alpha Subunit Narrower

Class Ia Phosphatidylinositol 3-Kinase, p55gamma Subunit Narrower

Class Ia Phosphatidylinositol 3-Kinase, p85alpha Subunit Narrower

Class Ia Phosphatidylinositol 3-Kinase, p110alpha Subunit Narrower

Class Ia Phosphatidylinositol 3-Kinase, p50alpha Subunit Narrower

Class Ia Phosphatidylinositol 3-Kinase MeSH Descriptor Data 2023