MeSH Browser

MeSH Heading: Spike Glycoprotein, Coronavirus
Tree Number(s): D12.776.543.512.500.665; D12.776.964.970.880.910.665
Unique ID: D064370
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D064370
Scope Note: A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.
Entry Term(s): E2 Spike Glycoprotein, Coronavirus; Glycoprotein S, Coronavirus; Spike Glycoprotein S1, Coronavirus; Spike Glycoprotein, Bovine Coronavirus; Spike Glycoproteins, Coronavirus; Spike Protein S2, Coronavirus; Spike Protein, Coronavirus
Previous Indexing: Membrane Glycoproteins (1991-2013); Viral Envelope Proteins (1983-2013); Viral Proteins (1979-1982)
Public MeSH Note: 2014; was indexed under MEMBRANE GLYCOPROTEINS 1991-2013 and VIRAL ENVELOPE PROTEINS 1991-2013
History Note: 2014
Date Established: 2014/01/01
Date of Entry: 2013/07/08
Revision Date: 2020/06/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0581462
Scope Note: A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.
Terms: Spike Glycoprotein, Coronavirus Preferred Term
Term UI T837945
Date02/27/2013
LexicalTag NON
ThesaurusID NLM (1991); Glycoprotein S, Coronavirus
Term UI T837950
Date02/27/2013
LexicalTag NON
ThesaurusID NLM (1991); Spike Glycoproteins, Coronavirus
Term UI T837422
Date02/15/2013
LexicalTag NON
ThesaurusID NLM (2014); Spike Protein, Coronavirus
Term UI T837946
Date02/27/2013
LexicalTag NON
ThesaurusID NLM (1991)

Spike Glycoprotein, Coronavirus MeSH Descriptor Data 2025