MeSH Browser

MeSH Heading: Receptors, N-Methyl-D-Aspartate
Tree Number(s): D12.776.157.530.400.400.500.500; D12.776.543.550.450.500.200.500; D12.776.543.585.400.500.200.500; D12.776.543.750.720.200.450.400.500
Unique ID: D016194
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016194
Scope Note: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
Entry Version: RECEPT NMDA
Entry Term(s): N-Methyl-D-Aspartate Receptor; N-Methyl-D-Aspartate Receptors; N-Methylaspartate Receptors; NMDA Receptor; NMDA Receptor-Ionophore Complex; NMDA Receptors; Receptors, N-Methylaspartate; Receptors, NMDA
Registry Numbers: 0
Previous Indexing: Receptors, Cell Surface (1973-1984); Receptors, Neurotransmitter (1985-1990)
Public MeSH Note: 93; was RECEPTOR, N-METHYL-D-ASPARTATE 1991-92; N-METHYL-D-ASPARTATE RECEPTORS was N-METHYL-D-ASPARTATE RECEPTOR see RECEPTOR, N-METHYL-D-ASPARTATE 1991-92
Online Note: use RECEPTORS, N-METHYL-D-ASPARTATE to search RECEPTOR, N-METHYL-D-ASPARTATE & N-METHYL-D-ASPARTATE RECEPTOR 1991-92
History Note: 93; was RECEPTOR, N-METHYL-D-ASPARTATE 1991-92; N-METHYL-D-ASPARTATE RECEPTORS was N-METHYL-D-ASPARTATE RECEPTOR see RECEPTOR, N-METHYL-D-ASPARTATE 1991-92
Date Established: 1991/01/01
Date of Entry: 1990/05/31
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Membrane Transport Proteins [D12.776.157.530]
      - Ion Channels [D12.776.157.530.400]
        
        Ligand-Gated Ion Channels [D12.776.157.530.400.400]
        
        Receptors, Ionotropic Glutamate [D12.776.157.530.400.400.500]
        
        Receptors, AMPA [D12.776.157.530.400.400.500.100]
        
        Receptors, Kainic Acid [D12.776.157.530.400.400.500.200]
        
        Receptors, N-Methyl-D-Aspartate [D12.776.157.530.400.400.500.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Glycoproteins [D12.776.543.550]
      - Ion Channels [D12.776.543.550.450]
        
        Ligand-Gated Ion Channels [D12.776.543.550.450.500]
        
        Receptors, Ionotropic Glutamate [D12.776.543.550.450.500.200]
        
        Receptors, AMPA [D12.776.543.550.450.500.200.100]
        
        Receptors, Kainic Acid [D12.776.543.550.450.500.200.200]
        
        Receptors, N-Methyl-D-Aspartate [D12.776.543.550.450.500.200.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Membrane Transport Proteins [D12.776.543.585]
      - Ion Channels [D12.776.543.585.400]
        
        Ligand-Gated Ion Channels [D12.776.543.585.400.500]
        
        Receptors, Ionotropic Glutamate [D12.776.543.585.400.500.200]
        
        Receptors, AMPA [D12.776.543.585.400.500.200.100]
        
        Receptors, Kainic Acid [D12.776.543.585.400.500.200.200]
        
        Receptors, N-Methyl-D-Aspartate [D12.776.543.585.400.500.200.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Membrane Proteins [D12.776.543]
    - Receptors, Cell Surface [D12.776.543.750]
      - Receptors, Neurotransmitter [D12.776.543.750.720]
        
        Receptors, Amino Acid [D12.776.543.750.720.200]
        
        Receptors, Glutamate [D12.776.543.750.720.200.450]
        
        Receptors, Ionotropic Glutamate [D12.776.543.750.720.200.450.400]
        
        Receptors, AMPA [D12.776.543.750.720.200.450.400.100]
        
        Receptors, Kainic Acid [D12.776.543.750.720.200.450.400.200]
        
        Receptors, N-Methyl-D-Aspartate [D12.776.543.750.720.200.450.400.500]

Receptors, N-Methyl-D-Aspartate Preferred

Concept UI: M0024713
Registry Numbers: 0
Scope Note: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
Terms: Receptors, N-Methyl-D-Aspartate Preferred Term
Term UI T048134
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1991); NMDA Receptor-Ionophore Complex
Term UI T048132
Date02/20/1990
LexicalTag NON
ThesaurusID NLM (1991); NMDA Receptor
Term UI T000996199
Date11/14/2019
LexicalTag NON
ThesaurusID NLM (2021); N-Methyl-D-Aspartate Receptors
Term UI T048133
Date02/20/1990
LexicalTag NON
ThesaurusID NLM (1991); N-Methylaspartate Receptors
Term UI T048135
Date04/17/1992
LexicalTag NON
ThesaurusID NLM (1993); Receptors, N-Methylaspartate
Term UI T048136
Date02/20/1990
LexicalTag NON
ThesaurusID NLM (1991); Receptors, NMDA
Term UI T048137
Date02/22/1993
LexicalTag NON
ThesaurusID NLM (1994); NMDA Receptors
Term UI T048138
Date02/22/1993
LexicalTag NON
ThesaurusID NLM (1994); N-Methyl-D-Aspartate Receptor
Term UI T000996330
Date11/14/2019
LexicalTag NON
ThesaurusID NLM (2021)

Receptors, N-Methyl-D-Aspartate MeSH Descriptor Data 2024