MeSH Browser

MeSH Heading: Serine Peptidase Inhibitor Kazal-Type 5
Tree Number(s): D12.644.822.750.250; D12.776.815.688.250
Unique ID: D000074163
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074163
Scope Note: A secreted serine peptidase inhibitor that consists of 15 KAZAL MOTIFS and inhibits KALLIKREINS KLK5, KLK7, and KLK14 as well as TRYPSIN. It plays important roles in protecting MUCOSA against infection and inflammation, and in maintaining the integrity of the skin. Mutations in the SPINK5 gene are associated with NETHERTON SYNDROME.
Entry Term(s): LEKTI Protein; Lympho-Epithelial Kazal-Type Inhibitor; SPINK5 Protein; Serine Protease Inhibitor Kazal-Type 5
Previous Indexing: Carrier Proteins (1999-2017); Proteinase Inhibitory Proteins, Secretory (2005-2017)
See Also: Kazal Motifs; Netherton Syndrome
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2022/07/12

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000625733
Scope Note: A secreted serine peptidase inhibitor that consists of 15 KAZAL MOTIFS and inhibits KALLIKREINS KLK5, KLK7, and KLK14 as well as TRYPSIN. It plays important roles in protecting MUCOSA against infection and inflammation, and in maintaining the integrity of the skin. Mutations in the SPINK5 gene are associated with NETHERTON SYNDROME.
Terms: Serine Peptidase Inhibitor Kazal-Type 5 Preferred Term
Term UI T000914372
Date01/19/2017
LexicalTag NON
ThesaurusID NLM (2018); Serine Protease Inhibitor Kazal-Type 5
Term UI T000914371
Date01/19/2017
LexicalTag NON
ThesaurusID NLM (2018); Lympho-Epithelial Kazal-Type Inhibitor
Term UI T000914373
Date01/19/2017
LexicalTag NON
ThesaurusID NLM (2018); SPINK5 Protein
Term UI T000914374
Date01/19/2017
LexicalTag ACX
ThesaurusID NLM (2018); LEKTI Protein
Term UI T000914375
Date01/19/2017
LexicalTag ACX
ThesaurusID NLM (2018)

Serine Peptidase Inhibitor Kazal-Type 5 MeSH Descriptor Data 2025