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Serine Peptidase Inhibitor Kazal-Type 5 MeSH Descriptor Data 2022


MeSH Heading
Serine Peptidase Inhibitor Kazal-Type 5
Tree Number(s)
D12.644.822.750.250
D12.776.645.688.250
Unique ID
D000074163
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074163
Scope Note
A secreted serine peptidase inhibitor that consists of 15 KAZAL MOTIFS and inhibits KALLIKREINS KLK5, KLK7, and KLK14 as well as TRYPSIN. It plays important roles in protecting MUCOSA against infection and inflammation, and in maintaining the integrity of the skin. Mutations in the SPINK5 gene are associated with NETHERTON SYNDROME.
Entry Term(s)
LEKTI Protein
Lympho-Epithelial Kazal-Type Inhibitor
SPINK5 Protein
Serine Protease Inhibitor Kazal-Type 5
Registry Number
0
Previous Indexing
Carrier Proteins (1999-2017)
Proteinase Inhibitory Proteins, Secretory (2005-2017)
See Also
Kazal Motifs
Netherton Syndrome
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/02/24
Serine Peptidase Inhibitor Kazal-Type 5 Preferred
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