MeSH Browser

MeSH Heading: Kazal Motifs
Tree Number(s): G02.111.570.820.709.275.500.490
Unique ID: D000074161
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074161
Scope Note: Highly conserved protein domains characteristic of SERINE PROTEASE INHIBITORS, KAZAL TYPE. They generally occur as tandem repeats, with each domain consisting of approximately 60 amino acids that form a large extended amino acid chain, two short ALPHA-HELICES, and a three-stranded anti-parallel BETA-SHEET. Kazal-like domains also occur in the extracellular portions of AGRIN.
Entry Term(s): Kazal Domain; Kazal Domains; Kazal Motif
Previous Indexing: Amino Acid Motifs (2008-2017); Amino Acid Sequence (2004-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/27

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Chemical Phenomena [G02]
- Biochemical Phenomena [G02.111]
  - Molecular Structure [G02.111.570]
    - Molecular Conformation [G02.111.570.820]
      - Protein Conformation [G02.111.570.820.709]
        
        Protein Structural Elements [G02.111.570.820.709.275]
        
        Amino Acid Motifs [G02.111.570.820.709.275.500]
        
        Ankyrin Repeat [G02.111.570.820.709.275.500.030]
        
        AT-Hook Motifs [G02.111.570.820.709.275.500.050]
        
        Cystine Knot Motifs [G02.111.570.820.709.275.500.127]
        
        F-Box Motifs [G02.111.570.820.709.275.500.205]
        
        Helix-Loop-Helix Motifs [G02.111.570.820.709.275.500.360]
        
        Immunoreceptor Tyrosine-Based Activation Motif [G02.111.570.820.709.275.500.440]
        
        Immunoreceptor Tyrosine-Based Inhibition Motif [G02.111.570.820.709.275.500.480]
        
        Kazal Motifs [G02.111.570.820.709.275.500.490]
        
        Kelch Repeat [G02.111.570.820.709.275.500.500]
        
        Leucine Zippers [G02.111.570.820.709.275.500.520]
        
        Poly-ADP-Ribose Binding Motif [G02.111.570.820.709.275.500.695]
        
        RNA-Binding Motifs [G02.111.570.820.709.275.500.869]
        
        Sterile Alpha Motif [G02.111.570.820.709.275.500.898]
        
        AAA Domain [G02.111.570.820.709.275.500.913]
        
        Tetratricopeptide Repeat [G02.111.570.820.709.275.500.920]
        
        WD40 Repeats [G02.111.570.820.709.275.500.927]
        
        Zinc Fingers [G02.111.570.820.709.275.500.985]

Kazal Motifs Preferred

Concept UI: M000625729
Scope Note: Highly conserved protein domains characteristic of SERINE PROTEASE INHIBITORS, KAZAL TYPE. They generally occur as tandem repeats, with each domain consisting of approximately 60 amino acids that form a large extended amino acid chain, two short ALPHA-HELICES, and a three-stranded anti-parallel BETA-SHEET. Kazal-like domains also occur in the extracellular portions of AGRIN.
Terms: Kazal Motifs Preferred Term
Term UI T000914359
Date01/19/2017
LexicalTag NON
ThesaurusID NLM (2018); Kazal Domains
Term UI T000914356
Date01/19/2017
LexicalTag NON
ThesaurusID NLM (2018); Kazal Domain
Term UI T000914357
Date01/19/2017
LexicalTag NON
ThesaurusID NLM (2018); Kazal Motif
Term UI T000914358
Date01/19/2017
LexicalTag NON
ThesaurusID NLM (2018)

Kazal Motifs MeSH Descriptor Data 2025