MeSH Browser

MeSH Heading: Immunoreceptor Tyrosine-Based Inhibition Motif
Tree Number(s): G02.111.570.820.709.275.500.480
Unique ID: D061626
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D061626
Scope Note: A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins that negatively regulate the signal transduction processes emanating from transmembrane proteins containing IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS. The CONSENSUS SEQUENCE of this motif is I(or V)LXYXXL(or V) (where X denotes any amino acid). Also known as ITIM motifs.
Entry Term(s): Immune Receptor Tyrosine-Based Inhibition Motif; Immuno-Receptor Tyrosine-Based Inhibition Motif
Public MeSH Note: 2013
History Note: 2013
Date Established: 2013/01/01
Date of Entry: 2012/07/03
Revision Date: 2016/07/05

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Chemical Phenomena [G02]
- Biochemical Phenomena [G02.111]
  - Molecular Structure [G02.111.570]
    - Molecular Conformation [G02.111.570.820]
      - Protein Conformation [G02.111.570.820.709]
        
        Protein Structural Elements [G02.111.570.820.709.275]
        
        Amino Acid Motifs [G02.111.570.820.709.275.500]
        
        Ankyrin Repeat [G02.111.570.820.709.275.500.030]
        
        AT-Hook Motifs [G02.111.570.820.709.275.500.050]
        
        Cystine Knot Motifs [G02.111.570.820.709.275.500.127]
        
        F-Box Motifs [G02.111.570.820.709.275.500.205]
        
        Helix-Loop-Helix Motifs [G02.111.570.820.709.275.500.360]
        
        Immunoreceptor Tyrosine-Based Activation Motif [G02.111.570.820.709.275.500.440]
        
        Immunoreceptor Tyrosine-Based Inhibition Motif [G02.111.570.820.709.275.500.480]
        
        Kazal Motifs [G02.111.570.820.709.275.500.490]
        
        Kelch Repeat [G02.111.570.820.709.275.500.500]
        
        Leucine Zippers [G02.111.570.820.709.275.500.520]
        
        Poly-ADP-Ribose Binding Motif [G02.111.570.820.709.275.500.695]
        
        RNA-Binding Motifs [G02.111.570.820.709.275.500.869]
        
        Sterile Alpha Motif [G02.111.570.820.709.275.500.898]
        
        AAA Domain [G02.111.570.820.709.275.500.913]
        
        Tetratricopeptide Repeat [G02.111.570.820.709.275.500.920]
        
        WD40 Repeats [G02.111.570.820.709.275.500.927]
        
        Zinc Fingers [G02.111.570.820.709.275.500.985]

Immunoreceptor Tyrosine-Based Inhibition Motif Preferred

Concept UI: M0559750
Scope Note: A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins that negatively regulate the signal transduction processes emanating from transmembrane proteins containing IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS. The CONSENSUS SEQUENCE of this motif is I(or V)LXYXXL(or V) (where X denotes any amino acid). Also known as ITIM motifs.
Terms: Immunoreceptor Tyrosine-Based Inhibition Motif Preferred Term
Term UI T794775
Date08/02/2011
LexicalTag NON
ThesaurusID NLM (2013); Immuno-Receptor Tyrosine-Based Inhibition Motif
Term UI T794776
Date08/02/2011
LexicalTag NON
ThesaurusID NLM (2013); Immune Receptor Tyrosine-Based Inhibition Motif
Term UI T794777
Date08/02/2011
LexicalTag NON
ThesaurusID NLM (2013)

Immunoreceptor Tyrosine-Based Inhibition Motif MeSH Descriptor Data 2025