MeSH Browser

MeSH Heading: Tetratricopeptide Repeat
Tree Number(s): G02.111.570.060.720.394; G02.111.570.820.709.275.500.920; G02.111.570.820.709.275.750.500.829; G02.111.570.820.709.275.875.394
Unique ID: D000074436
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074436
Scope Note: A structural motif present in a variety of proteins that mediates protein-protein interactions and assembly of multiprotein complexes. It consists of 3 to 16 tandem repeats of 34 amino acids, mostly of small and large hydrophobic residues, that form ALPHA-HELIX pairs.
Entry Term(s): TPR Domain; TPR Motif; Tetratricopeptide Motif; Tetratricopeptide Repeat Domain
Previous Indexing: Amino Acid Sequence (1991-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/04/06

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Chemical Phenomena [G02]
- Biochemical Phenomena [G02.111]
  - Molecular Structure [G02.111.570]
    - Amino Acid Sequence [G02.111.570.060]
      - Repetitive Sequences, Amino Acid [G02.111.570.060.720]
        
        Ankyrin Repeat [G02.111.570.060.720.030]
        
        Kelch Repeat [G02.111.570.060.720.273]
        
        Tetratricopeptide Repeat [G02.111.570.060.720.394]
        
        WD40 Repeats [G02.111.570.060.720.515]

Chemical Phenomena [G02]
- Biochemical Phenomena [G02.111]
  - Molecular Structure [G02.111.570]
    - Molecular Conformation [G02.111.570.820]
      - Protein Conformation [G02.111.570.820.709]
        
        Protein Structural Elements [G02.111.570.820.709.275]
        
        Amino Acid Motifs [G02.111.570.820.709.275.500]
        
        Ankyrin Repeat [G02.111.570.820.709.275.500.030]
        
        AT-Hook Motifs [G02.111.570.820.709.275.500.050]
        
        Cystine Knot Motifs [G02.111.570.820.709.275.500.127]
        
        F-Box Motifs [G02.111.570.820.709.275.500.205]
        
        Helix-Loop-Helix Motifs [G02.111.570.820.709.275.500.360]
        
        Immunoreceptor Tyrosine-Based Activation Motif [G02.111.570.820.709.275.500.440]
        
        Immunoreceptor Tyrosine-Based Inhibition Motif [G02.111.570.820.709.275.500.480]
        
        Kazal Motifs [G02.111.570.820.709.275.500.490]
        
        Kelch Repeat [G02.111.570.820.709.275.500.500]
        
        Leucine Zippers [G02.111.570.820.709.275.500.520]
        
        Poly-ADP-Ribose Binding Motif [G02.111.570.820.709.275.500.695]
        
        RNA-Binding Motifs [G02.111.570.820.709.275.500.869]
        
        Sterile Alpha Motif [G02.111.570.820.709.275.500.898]
        
        AAA Domain [G02.111.570.820.709.275.500.913]
        
        Tetratricopeptide Repeat [G02.111.570.820.709.275.500.920]
        
        WD40 Repeats [G02.111.570.820.709.275.500.927]
        
        Zinc Fingers [G02.111.570.820.709.275.500.985]

Chemical Phenomena [G02]
- Biochemical Phenomena [G02.111]
  - Molecular Structure [G02.111.570]
    - Molecular Conformation [G02.111.570.820]
      - Protein Conformation [G02.111.570.820.709]
        
        Protein Structural Elements [G02.111.570.820.709.275]
        
        Protein Domains [G02.111.570.820.709.275.750]
        
        Protein Interaction Domains and Motifs [G02.111.570.820.709.275.750.500]
        
        Ankyrin Repeat [G02.111.570.820.709.275.750.500.080]
        
        B30.2-SPRY Domain [G02.111.570.820.709.275.750.500.290]
        
        BTB-POZ Domain [G02.111.570.820.709.275.750.500.343]
        
        Death Domain Superfamily [G02.111.570.820.709.275.750.500.395]
        
        FERM Domains [G02.111.570.820.709.275.750.500.422]
        
        Kelch Repeat [G02.111.570.820.709.275.750.500.448]
        
        MYND Domains [G02.111.570.820.709.275.750.500.474]
        
        PDZ Domains [G02.111.570.820.709.275.750.500.500]
        
        RING Finger Domains [G02.111.570.820.709.275.750.500.625]
        
        src Homology Domains [G02.111.570.820.709.275.750.500.750]
        
        Sterile Alpha Motif [G02.111.570.820.709.275.750.500.813]
        
        Tetratricopeptide Repeat [G02.111.570.820.709.275.750.500.829]
        
        Tudor Domain [G02.111.570.820.709.275.750.500.844]
        
        WD40 Repeats [G02.111.570.820.709.275.750.500.875]
        
        WW Domains [G02.111.570.820.709.275.750.500.937]

Chemical Phenomena [G02]
- Biochemical Phenomena [G02.111]
  - Molecular Structure [G02.111.570]
    - Molecular Conformation [G02.111.570.820]
      - Protein Conformation [G02.111.570.820.709]
        
        Protein Structural Elements [G02.111.570.820.709.275]
        
        Repetitive Sequences, Amino Acid [G02.111.570.820.709.275.875]
        
        Ankyrin Repeat [G02.111.570.820.709.275.875.030]
        
        Kelch Repeat [G02.111.570.820.709.275.875.273]
        
        Tetratricopeptide Repeat [G02.111.570.820.709.275.875.394]
        
        WD40 Repeats [G02.111.570.820.709.275.875.515]

Tetratricopeptide Repeat Preferred

Concept UI: M000626591
Scope Note: A structural motif present in a variety of proteins that mediates protein-protein interactions and assembly of multiprotein complexes. It consists of 3 to 16 tandem repeats of 34 amino acids, mostly of small and large hydrophobic residues, that form ALPHA-HELIX pairs.
Terms: Tetratricopeptide Repeat Preferred Term
Term UI T000916006
Date02/17/2017
LexicalTag NON
ThesaurusID NLM (2018); TPR Domain
Term UI T000916008
Date02/17/2017
LexicalTag ABX
ThesaurusID NLM (2018); Tetratricopeptide Motif
Term UI T000916009
Date02/17/2017
LexicalTag NON
ThesaurusID NLM (2018); Tetratricopeptide Repeat Domain
Term UI T000916010
Date02/17/2017
LexicalTag NON
ThesaurusID NLM (2018); TPR Motif
Term UI T000916007
Date02/17/2017
LexicalTag ABX
ThesaurusID NLM (2018)

Tetratricopeptide Repeat MeSH Descriptor Data 2025