MeSH Browser

MeSH Heading: AAA Domain
Tree Number(s): G02.111.570.820.709.275.500.913
Unique ID: D000074182
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074182
Scope Note: An approximately 250 amino acid domain common to AAA ATPases and AAA Proteins. It consists of a highly conserved N-terminal P-Loop ATPase subdomain with an alpha-beta-alpha conformation, and a less-conserved C-terminal subdomain with an all alpha conformation. The N-terminal subdomain includes Walker A and Walker B motifs which function in ATP binding and hydrolysis.
Entry Term(s): A-Loop; AAA Domains; AAA Modules; AAA+ Domain; AAA+ Modules; P-Loop; Walker A Motif; Walker B Motif; Walker Motif; Walker Motifs
Previous Indexing: Amino Acid Sequence (1990-2017)
See Also: ATPases Associated with Diverse Cellular Activities
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/02/24

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Chemical Phenomena [G02]
- Biochemical Phenomena [G02.111]
  - Molecular Structure [G02.111.570]
    - Molecular Conformation [G02.111.570.820]
      - Protein Conformation [G02.111.570.820.709]
        
        Protein Structural Elements [G02.111.570.820.709.275]
        
        Amino Acid Motifs [G02.111.570.820.709.275.500]
        
        Ankyrin Repeat [G02.111.570.820.709.275.500.030]
        
        AT-Hook Motifs [G02.111.570.820.709.275.500.050]
        
        Cystine Knot Motifs [G02.111.570.820.709.275.500.127]
        
        F-Box Motifs [G02.111.570.820.709.275.500.205]
        
        Helix-Loop-Helix Motifs [G02.111.570.820.709.275.500.360]
        
        Immunoreceptor Tyrosine-Based Activation Motif [G02.111.570.820.709.275.500.440]
        
        Immunoreceptor Tyrosine-Based Inhibition Motif [G02.111.570.820.709.275.500.480]
        
        Kazal Motifs [G02.111.570.820.709.275.500.490]
        
        Kelch Repeat [G02.111.570.820.709.275.500.500]
        
        Leucine Zippers [G02.111.570.820.709.275.500.520]
        
        Poly-ADP-Ribose Binding Motif [G02.111.570.820.709.275.500.695]
        
        RNA-Binding Motifs [G02.111.570.820.709.275.500.869]
        
        Sterile Alpha Motif [G02.111.570.820.709.275.500.898]
        
        AAA Domain [G02.111.570.820.709.275.500.913]
        
        Tetratricopeptide Repeat [G02.111.570.820.709.275.500.920]
        
        WD40 Repeats [G02.111.570.820.709.275.500.927]
        
        Zinc Fingers [G02.111.570.820.709.275.500.985]

AAA Domain Preferred

Concept UI: M000626136
Scope Note: An approximately 250 amino acid domain common to AAA ATPases and AAA Proteins. It consists of a highly conserved N-terminal P-Loop ATPase subdomain with an alpha-beta-alpha conformation, and a less-conserved C-terminal subdomain with an all alpha conformation. The N-terminal subdomain includes Walker A and Walker B motifs which function in ATP binding and hydrolysis.
Terms: AAA Domain Preferred Term
Term UI T000915124
Date02/02/2017
LexicalTag ABX
ThesaurusID NLM (2018); AAA Modules
Term UI T000915137
Date02/02/2017
LexicalTag ABX
ThesaurusID NLM (2018); AAA+ Modules
Term UI T000915138
Date02/02/2017
LexicalTag ABX
ThesaurusID NLM (2018); AAA Domains
Term UI T000915140
Date02/02/2017
LexicalTag NON
ThesaurusID NLM (2018); AAA+ Domain
Term UI T000915125
Date02/02/2017
LexicalTag ABX
ThesaurusID NLM (2018)

Walker Motifs Narrower

Walker A Motif Narrower

Walker B Motif Narrower

A-Loop Related

AAA Domain MeSH Descriptor Data 2025