MeSH Browser

MeSH Heading: Immunoreceptor Tyrosine-Based Activation Motif
Tree Number(s): G02.111.570.820.709.275.500.440
Unique ID: D061625
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D061625
Scope Note: A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.
Entry Term(s): Immune Receptor Tyrosine-Based Activation Motif; Immuno-Receptor Tyrosine-Based Activation Motif
Public MeSH Note: 2013
History Note: 2013
Date Established: 2013/01/01
Date of Entry: 2012/07/03
Revision Date: 2016/07/05

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Chemical Phenomena [G02]
- Biochemical Phenomena [G02.111]
  - Molecular Structure [G02.111.570]
    - Molecular Conformation [G02.111.570.820]
      - Protein Conformation [G02.111.570.820.709]
        
        Protein Structural Elements [G02.111.570.820.709.275]
        
        Amino Acid Motifs [G02.111.570.820.709.275.500]
        
        Ankyrin Repeat [G02.111.570.820.709.275.500.030]
        
        AT-Hook Motifs [G02.111.570.820.709.275.500.050]
        
        Cystine Knot Motifs [G02.111.570.820.709.275.500.127]
        
        F-Box Motifs [G02.111.570.820.709.275.500.205]
        
        Helix-Loop-Helix Motifs [G02.111.570.820.709.275.500.360]
        
        Immunoreceptor Tyrosine-Based Activation Motif [G02.111.570.820.709.275.500.440]
        
        Immunoreceptor Tyrosine-Based Inhibition Motif [G02.111.570.820.709.275.500.480]
        
        Kazal Motifs [G02.111.570.820.709.275.500.490]
        
        Kelch Repeat [G02.111.570.820.709.275.500.500]
        
        Leucine Zippers [G02.111.570.820.709.275.500.520]
        
        Poly-ADP-Ribose Binding Motif [G02.111.570.820.709.275.500.695]
        
        RNA-Binding Motifs [G02.111.570.820.709.275.500.869]
        
        Sterile Alpha Motif [G02.111.570.820.709.275.500.898]
        
        AAA Domain [G02.111.570.820.709.275.500.913]
        
        Tetratricopeptide Repeat [G02.111.570.820.709.275.500.920]
        
        WD40 Repeats [G02.111.570.820.709.275.500.927]
        
        Zinc Fingers [G02.111.570.820.709.275.500.985]

Immunoreceptor Tyrosine-Based Activation Motif Preferred

Immunoreceptor Tyrosine-Based Activation Motif MeSH Descriptor Data 2025