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Immunoreceptor Tyrosine-Based Activation Motif MeSH Descriptor Data 2026


MeSH Heading
Immunoreceptor Tyrosine-Based Activation Motif
Tree Number(s)
G02.111.570.820.709.275.500.440
Unique ID
D061625
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D061625
Scope Note
A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.
Entry Term(s)
Immune Receptor Tyrosine-Based Activation Motif
Immuno-Receptor Tyrosine-Based Activation Motif
Public MeSH Note
2013
History Note
2013
Date Introduced
2013/01/01
Last Updated
2016/07/05
Immunoreceptor Tyrosine-Based Activation Motif Preferred
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