Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

PHD Zinc Fingers MeSH Descriptor Data 2026


MeSH Heading
PHD Zinc Fingers
Tree Number(s)
G02.111.570.820.709.275.500.985.438
Unique ID
D000075925
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000075925
Scope Note
Zinc finger domains of approximately 50 to 80 amino acids in length that are characterized by a conserved Cysteine(3)-Histidine-Cysteine(4) amino acid motif which coordinates binding of two zinc ions. They are similar structurally to RING FINGER DOMAINS, with a globular fold topology of two BETA-SHEETS and an ALPHA-HELIX. PHD fingers occur in many proteins that function in chromatin-mediated gene expression and EPIGENETICS such as POLYCOMB-GROUP PROTEINS.
Entry Term(s)
PHD Domains
PHD Finger Domain
PHD Fingers
PHD Motif
PHD Motifs
PHD Zinc Finger
Previous Indexing
Amino Acid Sequence (1995-2017)
Molecular Sequence Data (1995-2017)
Public MeSH Note
2018
History Note
2018
Date Introduced
2018/01/01
Last Updated
2018/01/01
PHD Zinc Fingers Preferred
page delivered in 0.141s