MeSH Browser

MeSH Heading: Lapatinib
Tree Number(s): D03.633.100.786.516
Unique ID: D000077341
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000077341
Scope Note: A quinazoline derivative that inhibits EPIDERMAL GROWTH FACTOR RECEPTOR and HER2 (RECEPTOR, ERBB-2) tyrosine kinases. It is used for the treatment of advanced or metastatic breast cancer, where tumors overexpress HER2.
Entry Term(s): GW 282974X; GW 572016; GW-282974X; GW-572016; GW282974X; GW572016; Lapatinib Ditosylate; N-(3-chloro-4-(((3-fluorobenzyl)oxy)phenyl)-6-(5-(((2-methylsulfonyl)ethyl)amino)methyl) -2-furyl)-4-quinazolinamine; Tykerb
Pharm Action: Antineoplastic Agents
Protein Kinase Inhibitors
Registry Number: 0VUA21238F
Related Numbers: G873GX646R
Public MeSH Note: 2019; LAPATINIB was indexed under QUINAZOLINES 2004-2018
History Note: 2019 (2004)
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/07/03

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Lapatinib MeSH Descriptor Data 2023