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Aprepitant MeSH Descriptor Data 2023


MeSH Heading
Aprepitant
Tree Number(s)
D03.383.533.640.125
Unique ID
D000077608
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000077608
Scope Note
A morpholine neurokinin-1 (NK1) receptor antagonist that is used in the management of nausea and vomiting caused by DRUG THERAPY, and for the prevention of POSTOPERATIVE NAUSEA AND VOMITING.
Entry Term(s)
(1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methylmorpholine
(2R)-(1R)-3,5-bis(Trifluoromethylphenyl)ethoxy)-(3S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazole)methyl-morpholine
Emend
L 754,030
L 754030
L-754,030
L-754030
MK 0517
MK 0869
MK 869
MK-0517
MK-0869
MK-869
MK0517
Pharm Action
Antiemetics
Neurokinin-1 Receptor Antagonists
Registry Number
1NF15YR6UY
CAS Type 1 Name
3H-1,2,4-Triazol-3-one, 5-(((2R,3S)-2-((1R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)-4-morpholinyl)methyl)-2,4-dihydro-
Public MeSH Note
2019; APREPITANT was indexed under MORPHOLINES 1998-2018
History Note
2019 (1998)
Date Established
2019/01/01
Date of Entry
2018/07/09
Revision Date
2018/04/09
Aprepitant Preferred
MK 869 Narrower
(2R)-(1R)-3,5-bis(Trifluoromethylphenyl)ethoxy)-(3S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazole)methyl-morpholine Related
MK 0517 Narrower
(1-(3,5-bis(Trifluoromethyl)phenyl)ethoxy)-3-(fluoro)phenyl-4-(3-oxo-1,2,4-triazol-5-yl)methylmorpholine Narrower
Emend Narrower
L 754030 Narrower
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