3C Viral Proteases MeSH Descriptor Data 2023

MeSH Heading: 3C Viral Proteases
Tree Number(s): D08.811.277.656.262.500.108; D08.811.277.656.979.250; D12.776.964.900.500.500
Unique ID: D000086042
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000086042
Scope Note: A class of cysteine proteases which play an essential role in VIRUS REPLICATION. They cleave precursor viral POLYPROTEINS to produce functional proteins and enzymes.
Entry Term(s): 3C-like Viral Proteases; 3Cpro Proteinases
Registry Number: EC 3.4.22.28
Related Numbers: EC 3.4.22.28
Previous Indexing: Peptide Hydrolases (1966-2020); Viral Proteins (1965-2020)
Public MeSH Note: 2021
History Note: 2021
Date Established: 2021/01/01
Date of Entry: 2020/07/07
Revision Date: 2020/06/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Cysteine Proteases [D08.811.277.656.262]
        
        Cysteine Endopeptidases [D08.811.277.656.262.500]
        
        Bromelains [D08.811.277.656.262.500.096]
        
        3C Viral Proteases [D08.811.277.656.262.500.108]
        
        Coronavirus 3C Proteases [D08.811.277.656.262.500.108.500]
        
        Calpain [D08.811.277.656.262.500.120]
        
        Caspases [D08.811.277.656.262.500.126]
        
        Cathepsin B [D08.811.277.656.262.500.133]
        
        Cathepsin F [D08.811.277.656.262.500.146]
        
        Cathepsin H [D08.811.277.656.262.500.153]
        
        Cathepsin K [D08.811.277.656.262.500.156]
        
        Cathepsin L [D08.811.277.656.262.500.157]
        
        Cathepsin W [D08.811.277.656.262.500.158]
        
        Chymopapain [D08.811.277.656.262.500.160]
        
        Ficain [D08.811.277.656.262.500.350]
        
        Gingipain Cysteine Endopeptidases [D08.811.277.656.262.500.468]
        
        Papain [D08.811.277.656.262.500.585]
        
        Separase [D08.811.277.656.262.500.792]
        
        Viral Papain-like Proteases [D08.811.277.656.262.500.896]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Viral Proteases [D08.811.277.656.979]
        
        3C Viral Proteases [D08.811.277.656.979.250]
        
        Coronavirus 3C Proteases [D08.811.277.656.979.250.500]
        
        HIV Protease [D08.811.277.656.979.500]
        
        Viral Papain-like Proteases [D08.811.277.656.979.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Viral Proteins [D12.776.964]
    - Viral Nonstructural Proteins [D12.776.964.900]
      - Viral Proteases [D12.776.964.900.500]
        
        3C Viral Proteases [D12.776.964.900.500.500]
        
        Coronavirus 3C Proteases [D12.776.964.900.500.500.500]
        
        HIV Protease [D12.776.964.900.500.625]
        
        Viral Papain-like Proteases [D12.776.964.900.500.750]

3C Viral Proteases Preferred

3C-like Viral Proteases Narrower

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