MeSH Browser

MeSH Heading: Asparaginyl Endopeptidase
Tree Number(s): D08.811.277.656.262.500.102; D08.811.277.656.300.200.001
Unique ID: D000099240
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099240
Scope Note: A cysteine endopeptidase that occurs in LYSOSOMES of MACROPHAGES where it hydrolyzes molecules containing ASPARAGINE. It plays a critical role in ANTIGEN PRESENTATION.
Entry Term(s): Asparagine Endopeptidase; Asparaginylendopeptidase; Delta Secretase; Legumain
Registry Numbers: EC 3.4.22.34
Public MeSH Note: 2026; ASPARAGINYL ENDOPEPTIDASE was indexed under CYSTEINE ENDOPEPTIDASES 2005-2025 and under ENDOPEPTIDASES 1991-2004
History Note: 2026 (1991); use ASPARAGINYLENDOPEPTIDASE (NM) 1991-2025
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000769010
Registry Numbers: EC 3.4.22.34
Scope Note: A cysteine endopeptidase that occurs in LYSOSOMES of MACROPHAGES where it hydrolyzes molecules containing ASPARAGINE. It plays a critical role in ANTIGEN PRESENTATION.
Terms: Asparaginyl Endopeptidase Preferred Term
Term UI T001148419
Date05/07/2025
LexicalTag NON
ThesaurusID NLM (2026); Asparagine Endopeptidase
Term UI T001148418
Date05/07/2025
LexicalTag NON
ThesaurusID NLM (2026); Asparaginylendopeptidase
Term UI T001148417
Date05/07/2025
LexicalTag NON
ThesaurusID NLM (2026); Delta Secretase
Term UI T001148420
Date05/07/2025
LexicalTag NON
ThesaurusID NLM (2026); Legumain
Term UI T001148421
Date05/07/2025
LexicalTag NON
ThesaurusID NLM (2026)

Asparaginyl Endopeptidase MeSH Descriptor Data 2026