MeSH Browser

MeSH Heading: Alkylating Agents
Tree Number(s): D27.505.519.124; D27.888.569.035
Unique ID: D000477
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000477
Scope Note: Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
Entry Term(s): Alkylating Agent; Alkylator; Alkylators
NLM Classification #: QV 269
Public MeSH Note: 66
History Note: 66(64)
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0000721
Scope Note: Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
Terms: Alkylating Agents Preferred Term
Term UI T001416
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1964); Alkylators
Term UI T001417
Date10/20/1994
LexicalTag NON
ThesaurusID NLM (1996); Alkylator
Term UI T001078757
Date04/17/2020
LexicalTag NON
ThesaurusID NLM (2021); Alkylating Agent
Term UI T001078758
Date04/17/2020
LexicalTag NON
ThesaurusID NLM (2021)

Alkylating Agents MeSH Descriptor Data 2025