MeSH Browser

MeSH Heading: Amino Acid Chloromethyl Ketones
Tree Number(s): D12.125.065
Unique ID: D000590
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000590
Scope Note: Inhibitors of SERINE ENDOPEPTIDASES and sulfhydryl group-containing enzymes. They act as alkylating agents and are known to interfere in the translation process.
Entry Version: AACK
Entry Term(s): Peptide Chloromethyl Ketones
Pharm Action: Alkylating Agents
Protein Synthesis Inhibitors
Serine Proteinase Inhibitors
Previous Indexing: Peptides (1966-1976); specific amino acid (1966-1976)
Public MeSH Note: 77; TOSYLLYSINE CHLOROMETHYL KETONE was see under LYSINE 1975-76; TOSYLPHENYLALANYL CHLOROMETHYL KETONE was see under PHENYLALANINE 1975-76
History Note: 77
Date Established: 1977/01/01
Date of Entry: 1976/05/19
Revision Date: 1999/11/09

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Amino Acid Chloromethyl Ketones MeSH Descriptor Data 2025