MeSH Browser

MeSH Heading: Amoxapine
Tree Number(s): D03.633.300.347.500.040
Unique ID: D000657
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000657
Scope Note: The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both; it also blocks dopamine receptors. Amoxapine is used for the treatment of depression.
Entry Term(s): 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine; Asendin; Asendis; CL-67,772; Demolox; Desmethylloxapine; Défanyl
Pharm Action: Antidepressive Agents, Tricyclic
Neurotransmitter Uptake Inhibitors
Selective Serotonin Reuptake Inhibitors
Dopamine Antagonists
Adrenergic Uptake Inhibitors
Registry Numbers: R63VQ857OT; 0
Related Numbers: 14028-44-5
CAS Type 1 Name: Dibenz(b,f)(1,4)oxazepine, 2-chloro-11-(1-piperazinyl)-
Previous Indexing: Dibenzoxazepines (1971-1974); Piperazines (1971-1974)
Public MeSH Note: 91; was see under DIBENZOXAZEPINES 1975-90
History Note: 91(75); was see under DIBENZOXAZEPINES 1975-90
Date Established: 1991/01/01
Date of Entry: 1974/11/27
Revision Date: 2022/07/18

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0001008
Registry Numbers: R63VQ857OT
Related Numbers: 14028-44-5
Scope Note: The N-demethylated derivative of the antipsychotic agent LOXAPINE that works by blocking the reuptake of norepinephrine, serotonin, or both; it also blocks dopamine receptors. Amoxapine is used for the treatment of depression.
Terms: Amoxapine Preferred Term
Term UI T001967
Date01/01/1999
LexicalTag NON
ThesaurusID; Desmethylloxapine
Term UI T001970
Date09/18/1981
LexicalTag NON
ThesaurusID UNK (19XX); 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine
Term UI T001971
Date04/05/1995
LexicalTag NON
ThesaurusID

Amoxapine MeSH Descriptor Data 2024