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Arachidonate 12-Lipoxygenase MeSH Descriptor Data 2026
An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.
Entry Term(s)
12-Lipoxygenase
Arachidonic Acid 12-Lipoxygenase
Registry Numbers
EC 1.13.11.31
CAS Type 1 Name
Arachidonate:oxygen 12-oxidoreductase
Previous Indexing
Lipoxygenases (1974-1986)
Oxygenases (1966-1973)
Public MeSH Note
91; was see under ARACHIDONATE LIPOXYGENASES 1987-90
History Note
91(87); was see under ARACHIDONATE LIPOXYGENASES 1987-90
An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.