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Arachidonate 12-Lipoxygenase MeSH Descriptor Data 2025


MeSH Heading
Arachidonate 12-Lipoxygenase
Tree Number(s)
D08.811.682.690.416.583.500.060
D12.776.556.579.374.568.500.025
Unique ID
D001092
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D001092
Scope Note
An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.
Entry Term(s)
12-Lipoxygenase
Arachidonic Acid 12-Lipoxygenase
CAS Type 1 Name
Arachidonate:oxygen 12-oxidoreductase
Previous Indexing
Lipoxygenases (1974-1986)
Oxygenases (1966-1973)
Public MeSH Note
91; was see under ARACHIDONATE LIPOXYGENASES 1987-90
History Note
91(87); was see under ARACHIDONATE LIPOXYGENASES 1987-90
Entry Combination
antagonists & inhibitors:Lipoxygenase Inhibitors
Date Established
1991/01/01
Date of Entry
1986/06/16
Revision Date
2010/06/25
Arachidonate 12-Lipoxygenase Preferred
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