MeSH Browser

MeSH Heading: Arachidonate 5-Lipoxygenase
Tree Number(s): D08.811.682.690.416.583.500.055; D12.776.556.579.374.568.500.020
Unique ID: D001094
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D001094
Scope Note: An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.
Entry Term(s): 5-Lipoxygenase; Arachidonic Acid 5-Lipoxygenase; LTA4 Synthase; Leukotriene A Synthase; Leukotriene A4 Synthase; Leukotriene A4 Synthetase
CAS Type 1 Name: Arachidonate:oxygen 5-oxidoreductase
Previous Indexing: Lipoxygenases (1974-1986); Oxygenases (1966-1973)
Public MeSH Note: 91; was see under ARACHIDONATE LIPOXYGENASES 1987-90
History Note: 91(87); was see under ARACHIDONATE LIPOXYGENASES 1987-90
Entry Combination: antagonists & inhibitors:Lipoxygenase Inhibitors
Date Established: 1991/01/01
Date of Entry: 1986/06/16
Revision Date: 2010/06/25

Entry Combination: antagonists & inhibitors:Lipoxygenase Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0001648
Scope Note: An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.
Terms: Arachidonate 5-Lipoxygenase Preferred Term
Term UI T003320
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1987); 5-Lipoxygenase
Term UI T003319
Date06/16/1986
LexicalTag NON
ThesaurusID UNK (19XX); Arachidonic Acid 5-Lipoxygenase
Term UI T003321
Date06/16/1986
LexicalTag NON
ThesaurusID UNK (19XX); Leukotriene A Synthase
Term UI T003322
Date12/01/1987
LexicalTag NON
ThesaurusID UNK (19XX); Leukotriene A4 Synthase
Term UI T003323
Date04/03/1987
LexicalTag NON
ThesaurusID UNK (19XX); Leukotriene A4 Synthetase
Term UI T003324
Date04/03/1987
LexicalTag NON
ThesaurusID UNK (19XX); LTA4 Synthase
Term UI T003325
Date04/03/1987
LexicalTag NON
ThesaurusID UNK (19XX)

Arachidonate 5-Lipoxygenase MeSH Descriptor Data 2025