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3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester MeSH Descriptor Data 2021


MeSH Heading
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
Tree Number(s)
D03.383.725.203.600
D03.383.725.547.900
Unique ID
D001498
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D001498
Annotation
a calcium channel agonist
Scope Note
A dihydropyridine derivative, which, in contrast to NIFEDIPINE, functions as a calcium channel agonist. The compound facilitates Ca2+ influx through partially activated voltage-dependent Ca2+ channels, thereby causing vasoconstrictor and positive inotropic effects. It is used primarily as a research tool.
Entry Term(s)
BK-8644
Bay R5417
Bay-K-8644
Bay-K-8644, (+)-Isomer
Bay-K-8644, (+-)-Isomer
Bay-K-8644, (-)-Isomer
Bay-K8644
Bay-R-5417
Pharm Action
Calcium Channel Agonists
Registry Number
71145-03-4
Related Numbers
97217-82-8
98625-26-4
98791-67-4
CAS Type 1 Name
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, methyl ester
Previous Indexing
Nifedipine/analogs & derivatives (1975-1986)
Pyridines (1966-1974)
Public MeSH Note
87
History Note
87
Date Established
1987/01/01
Date of Entry
1986/06/02
Revision Date
2016/05/27
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester Preferred
Bay-R-5417 Narrower
Bay-K-8644, (+-)-Isomer Narrower
Bay-K-8644, (-)-Isomer Narrower
Bay-K-8644 Narrower
Bay-K-8644, (+)-Isomer Narrower
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