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Cardiac Glycosides MeSH Descriptor Data 2023


MeSH Heading
Cardiac Glycosides
Tree Number(s)
D04.210.500.155.580
D09.408.180
Unique ID
D002301
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D002301
Scope Note
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
Entry Term(s)
Cardiac Glycoside
Cardiotonic Steroid
Cardiotonic Steroids
Pharm Action
Anti-Arrhythmia Agents
Cardiotonic Agents
Enzyme Inhibitors
Registry Number
0
NLM Classification #
QV 153
Date Established
1966/01/01
Date of Entry
1999/01/01
Revision Date
2020/05/27
Cardiac Glycosides Preferred
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