MeSH Browser

MeSH Heading: Chlorambucil
Tree Number(s): D02.455.526.728.650.156
Unique ID: D002699
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D002699
Scope Note: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Entry Term(s): 4-(Bis(2-chloroethyl)amino)benzenebutanoic Acid; Amboclorin; CB-1348; Chloraminophene; Chlorbutin; Leukeran; Lympholysin; N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid; NSC-3088
Pharm Action: Antineoplastic Agents, Alkylating
Related Numbers: 305-03-3
CAS Type 1 Name: Benzenebutanoic acid, 4-(bis(2-chloroethyl)amino)-
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/07/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0004118
Related Numbers: 305-03-3
Scope Note: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Terms: Chlorambucil Preferred Term
Term UI T007810
Date01/01/1999
LexicalTag NON
ThesaurusID; Chloraminophene
Term UI T007811
Date01/08/1981
LexicalTag NON
ThesaurusID UNK (19XX); Chlorbutin
Term UI T007812
Date02/26/1982
LexicalTag NON
ThesaurusID UNK (19XX); N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid
Term UI T007814
Date03/05/1981
LexicalTag NON
ThesaurusID UNK (19XX); 4-(Bis(2-chloroethyl)amino)benzenebutanoic Acid
Term UI T007816
Date04/04/1995
LexicalTag NON
ThesaurusID NLM (1996)

Chlorambucil MeSH Descriptor Data 2025