MeSH Browser

MeSH Heading: Colorectal Neoplasms, Hereditary Nonpolyposis
Tree Number(s): C04.588.274.476.411.307.190; C04.700.250; C06.301.371.411.307.190; C06.405.249.411.307.190; C06.405.469.158.356.190; C06.405.469.491.307.190; C16.320.700.250; C18.452.284.255
Unique ID: D003123
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003123
Scope Note: A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.
Entry Version: COLORECTAL NEOPL HEREDITARY NONPOLYPOSIS
Entry Term(s): Colon Cancer, Familial Nonpolyposis; Colon Cancer, Familial Nonpolyposis, Type 1; Colorectal Cancer Hereditary Nonpolyposis; Colorectal Cancer, Hereditary Nonpolyposis, Type 1; Familial Nonpolyposis Colon Cancer; Familial Nonpolyposis Colon Cancer Type 1; Hereditary Nonpolyposis Colon Cancer; Hereditary Nonpolyposis Colorectal Cancer; Hereditary Nonpolyposis Colorectal Cancer Type 1; Hereditary Nonpolyposis Colorectal Neoplasms; Lynch Cancer Family Syndrome I; Lynch Syndrome; Lynch Syndrome I
NLM Classification #: WI 529
Public MeSH Note: 87
History Note: 87
Date Established: 1987/01/01
Date of Entry: 1986/06/24
Revision Date: 2021/03/05

Allowable Qualifiers: blood (BL)

blood supply (BS)

cerebrospinal fluid (CF)

chemically induced (CI)

chemistry (CH)

classification (CL)

complications (CO)

diagnosis (DI)

diagnostic imaging (DG)

diet therapy (DH)

drug therapy (DT)

economics (EC)

embryology (EM)

enzymology (EN)

epidemiology (EP)

ethnology (EH)

etiology (ET)

genetics (GE)

history (HI)

immunology (IM)

metabolism (ME)

microbiology (MI)

mortality (MO)

nursing (NU)

parasitology (PS)

pathology (PA)

physiopathology (PP)

prevention & control (PC)

psychology (PX)

radiotherapy (RT)

rehabilitation (RH)

secondary (SC)

surgery (SU)

therapy (TH)

ultrastructure (UL)

urine (UR)

veterinary (VE)

virology (VI)

Neoplasms [C04]
- Neoplasms by Site [C04.588]
  - Digestive System Neoplasms [C04.588.274]
    - Gastrointestinal Neoplasms [C04.588.274.476]
      - Intestinal Neoplasms [C04.588.274.476.411]
        
        Colorectal Neoplasms [C04.588.274.476.411.307]
        
        Adenomatous Polyposis Coli [C04.588.274.476.411.307.089]
        
        Colonic Neoplasms [C04.588.274.476.411.307.180]
        
        Colorectal Neoplasms, Hereditary Nonpolyposis [C04.588.274.476.411.307.190]
        
        Rectal Neoplasms [C04.588.274.476.411.307.790]

Neoplasms [C04]
- Neoplastic Syndromes, Hereditary [C04.700]

Digestive System Diseases [C06]
- Digestive System Neoplasms [C06.301]
  - Gastrointestinal Neoplasms [C06.301.371]
    - Intestinal Neoplasms [C06.301.371.411]
      - Colorectal Neoplasms [C06.301.371.411.307]
        
        Adenomatous Polyposis Coli [C06.301.371.411.307.090]
        
        Colonic Neoplasms [C06.301.371.411.307.180]
        
        Colorectal Neoplasms, Hereditary Nonpolyposis [C06.301.371.411.307.190]
        
        Rectal Neoplasms [C06.301.371.411.307.790]

Digestive System Diseases [C06]
- Gastrointestinal Diseases [C06.405]
  - Gastrointestinal Neoplasms [C06.405.249]
    - Intestinal Neoplasms [C06.405.249.411]
      - Colorectal Neoplasms [C06.405.249.411.307]
        
        Adenomatous Polyposis Coli [C06.405.249.411.307.090]
        
        Colonic Neoplasms [C06.405.249.411.307.180]
        
        Colorectal Neoplasms, Hereditary Nonpolyposis [C06.405.249.411.307.190]
        
        Rectal Neoplasms [C06.405.249.411.307.790]

Digestive System Diseases [C06]
- Gastrointestinal Diseases [C06.405]
  - Intestinal Diseases [C06.405.469]
    - Colonic Diseases [C06.405.469.158]
      - Colorectal Neoplasms [C06.405.469.158.356]
        
        Adenomatous Polyposis Coli [C06.405.469.158.356.090]
        
        Colonic Neoplasms [C06.405.469.158.356.180]
        
        Colorectal Neoplasms, Hereditary Nonpolyposis [C06.405.469.158.356.190]

Digestive System Diseases [C06]
- Gastrointestinal Diseases [C06.405]
  - Intestinal Diseases [C06.405.469]
    - Intestinal Neoplasms [C06.405.469.491]
      - Colorectal Neoplasms [C06.405.469.491.307]
        
        Adenomatous Polyposis Coli [C06.405.469.491.307.090]
        
        Colonic Neoplasms [C06.405.469.491.307.180]
        
        Colorectal Neoplasms, Hereditary Nonpolyposis [C06.405.469.491.307.190]
        
        Rectal Neoplasms [C06.405.469.491.307.790]

Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Genetic Diseases, Inborn [C16.320]
  - Neoplastic Syndromes, Hereditary [C16.320.700]

Nutritional and Metabolic Diseases [C18]
- Metabolic Diseases [C18.452]
  - DNA Repair-Deficiency Disorders [C18.452.284]

Colorectal Neoplasms, Hereditary Nonpolyposis Preferred

Concept UI: M0004834
Scope Note: A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.
Terms: Colorectal Neoplasms, Hereditary Nonpolyposis Preferred Term
Term UI T009104
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1987); Hereditary Nonpolyposis Colorectal Neoplasms
Term UI T009103
Date06/24/1986
LexicalTag NON
ThesaurusID; Familial Nonpolyposis Colon Cancer
Term UI T841938
Date04/18/2013
LexicalTag NON
ThesaurusID GHR (2014)

Hereditary Nonpolyposis Colorectal Cancer Narrower

Lynch Syndrome Narrower

Lynch Syndrome I Narrower

Colorectal Neoplasms, Hereditary Nonpolyposis MeSH Descriptor Data 2025