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Colorectal Neoplasms, Hereditary Nonpolyposis MeSH Descriptor Data 2023


MeSH Heading
Colorectal Neoplasms, Hereditary Nonpolyposis
Tree Number(s)
C04.588.274.476.411.307.190
C04.700.250
C06.301.371.411.307.190
C06.405.249.411.307.190
C06.405.469.158.356.190
C06.405.469.491.307.190
C16.320.700.250
C18.452.284.255
Unique ID
D003123
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D003123
Scope Note
A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.
Entry Version
COLORECTAL NEOPL HEREDITARY NONPOLYPOSIS
Entry Term(s)
Colon Cancer, Familial Nonpolyposis
Colon Cancer, Familial Nonpolyposis, Type 1
Colorectal Cancer Hereditary Nonpolyposis
Colorectal Cancer, Hereditary Nonpolyposis, Type 1
Familial Nonpolyposis Colon Cancer
Familial Nonpolyposis Colon Cancer Type 1
Hereditary Nonpolyposis Colon Cancer
Hereditary Nonpolyposis Colorectal Cancer
Hereditary Nonpolyposis Colorectal Cancer Type 1
Hereditary Nonpolyposis Colorectal Neoplasms
Lynch Cancer Family Syndrome I
Lynch Syndrome
Lynch Syndrome I
NLM Classification #
WI 529
Public MeSH Note
87
History Note
87
Date Established
1987/01/01
Date of Entry
1986/06/24
Revision Date
2021/03/05
Colorectal Neoplasms, Hereditary Nonpolyposis Preferred
Lynch Syndrome I Narrower
Lynch Syndrome Narrower
Hereditary Nonpolyposis Colorectal Cancer Narrower
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