MeSH Browser

MeSH Heading: Corticotropin-Releasing Hormone
Tree Number(s): D06.472.699.327.740.140; D12.644.400.400.740.140; D12.644.548.365.740.140; D12.776.631.650.405.740.140
Unique ID: D003346
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003346
Scope Note: A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.
Entry Version: CRH
Entry Term(s): ACTH-Releasing Factor; ACTH-Releasing Hormone; CRF (ACTH); CRF-41; Corticoliberin; Corticotropin-Releasing Factor; Corticotropin-Releasing Factor-41; Corticotropin-Releasing Hormone-41
Pharm Action: Hormones
Registry Numbers: 9015-71-8
NLM Classification #: WK 515
Previous Indexing: Adrenocorticotropic Hormone (1966-1967); Hypothalamo-Hypophyseal System/physiology (1966-1967)
See Also: Receptors, Corticotropin-Releasing Hormone
Public MeSH Note: 90; was CORTICOTROPIN RELEASING HORMONE 1974-89; was CORTICOTROPIN RELEASING FACTOR 1968-73
Online Note: use CORTICOTROPIN-RELEASING HORMONE to search CORTICOTROPIN RELEASING HORMONE 1974-89 & CORTICOTROPIN RELEASING FACTOR 1968-73
History Note: 90; was CORTICOTROPIN RELEASING HORMONE 1974-89; was CORTICOTROPIN RELEASING FACTOR 1968-73
Date Established: 1968/01/01
Date of Entry: 1999/01/01
Revision Date: 2015/11/23

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Peptide Hormones [D06.472.699]
    - Hypothalamic Hormones [D06.472.699.327]
      - Pituitary Hormone-Releasing Hormones [D06.472.699.327.740]
        
        Corticotropin-Releasing Hormone [D06.472.699.327.740.140]
        
        Gonadotropin-Releasing Hormone [D06.472.699.327.740.320]
        
        Growth Hormone-Releasing Hormone [D06.472.699.327.740.860]
        
        Thyrotropin-Releasing Hormone [D06.472.699.327.740.880]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Neuropeptides [D12.644.400]
    - Hypothalamic Hormones [D12.644.400.400]
      - Pituitary Hormone-Releasing Hormones [D12.644.400.400.740]
        
        Corticotropin-Releasing Hormone [D12.644.400.400.740.140]
        
        Gonadotropin-Releasing Hormone [D12.644.400.400.740.320]
        
        Growth Hormone-Releasing Hormone [D12.644.400.400.740.860]
        
        Thyrotropin-Releasing Hormone [D12.644.400.400.740.880]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Hormones [D12.644.548]
    - Hypothalamic Hormones [D12.644.548.365]
      - Pituitary Hormone-Releasing Hormones [D12.644.548.365.740]
        
        Corticotropin-Releasing Hormone [D12.644.548.365.740.140]
        
        Gonadotropin-Releasing Hormone [D12.644.548.365.740.320]
        
        Growth Hormone-Releasing Hormone [D12.644.548.365.740.860]
        
        Thyrotropin-Releasing Hormone [D12.644.548.365.740.880]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nerve Tissue Proteins [D12.776.631]
    - Neuropeptides [D12.776.631.650]
      - Hypothalamic Hormones [D12.776.631.650.405]
        
        Pituitary Hormone-Releasing Hormones [D12.776.631.650.405.740]
        
        Corticotropin-Releasing Hormone [D12.776.631.650.405.740.140]
        
        Gonadotropin-Releasing Hormone [D12.776.631.650.405.740.320]
        
        Growth Hormone-Releasing Hormone [D12.776.631.650.405.740.860]
        
        Thyrotropin-Releasing Hormone [D12.776.631.650.405.740.880]

Corticotropin-Releasing Hormone Preferred

Concept UI: M0005218
Registry Numbers: 9015-71-8
Scope Note: A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.
Terms: Corticotropin-Releasing Hormone Preferred Term
Term UI T009764
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1968); Corticotropin-Releasing Hormone-41
Term UI T009765
Date04/05/1989
LexicalTag NON
ThesaurusID NLM (1990); CRF-41
Term UI T009766
Date04/05/1989
LexicalTag ABB
ThesaurusID NLM (1990); ACTH-Releasing Hormone
Term UI T665334
Date01/30/2006
LexicalTag ACX
ThesaurusID NLM (2007); CRF (ACTH)
Term UI T665335
Date01/30/2006
LexicalTag ACR
ThesaurusID NLM (2007); ACTH-Releasing Factor
Term UI T009760
Date06/12/1986
LexicalTag ACX
ThesaurusID UNK (19XX); Corticoliberin
Term UI T009761
Date08/30/1982
LexicalTag NON
ThesaurusID UNK (19XX); Corticotropin-Releasing Factor
Term UI T009762
Date05/12/1989
LexicalTag NON
ThesaurusID NLM (1990); Corticotropin-Releasing Factor-41
Term UI T009763
Date05/12/1989
LexicalTag NON
ThesaurusID NLM (1990)

Corticotropin-Releasing Hormone MeSH Descriptor Data 2025