MeSH Browser

MeSH Heading: Gonadotropin-Releasing Hormone
Tree Number(s): D06.472.699.327.740.320; D12.644.400.400.740.320; D12.644.456.460; D12.644.548.365.740.320; D12.776.631.650.405.740.320
Unique ID: D007987
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D007987
Scope Note: A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
Entry Term(s): Cystorelin; Dirigestran; FSH-Releasing Hormone; Factrel; Gn-RH; GnRH; Gonadoliberin; Gonadorelin; Gonadorelin Acetate; Gonadorelin Hydrochloride; Kryptocur; LFRH; LH-FSH Releasing Hormone; LH-RH; LH-Releasing Hormone; LHFSH Releasing Hormone; LHFSHRH; LHRH; Luliberin; Luteinizing Hormone-Releasing Hormone
Related Numbers: 51952-41-1; 52699-48-6
CAS Type 1 Name: 5-oxoPro-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 (human or pig)
NLM Classification #: WK 515
See Also: Kallmann Syndrome; Receptors, LHRH
Public MeSH Note: 2007; see PITUITARY HORMONE RELEASING HORMONES 1977-1990, see LH-FSH RELEASING HORMONE 1974-1990
History Note: 2007 (1974)
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2015/11/23

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analogs & derivatives (AA)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
  - Peptide Hormones [D06.472.699]
    - Hypothalamic Hormones [D06.472.699.327]
      - Pituitary Hormone-Releasing Hormones [D06.472.699.327.740]
        
        Corticotropin-Releasing Hormone [D06.472.699.327.740.140]
        
        Gonadotropin-Releasing Hormone [D06.472.699.327.740.320]
        
        Buserelin [D06.472.699.327.740.320.100]
        
        Goserelin [D06.472.699.327.740.320.340]
        
        Leuprolide [D06.472.699.327.740.320.400]
        
        Nafarelin [D06.472.699.327.740.320.580]
        
        Triptorelin Pamoate [D06.472.699.327.740.320.790]
        
        Growth Hormone-Releasing Hormone [D06.472.699.327.740.860]
        
        Thyrotropin-Releasing Hormone [D06.472.699.327.740.880]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Neuropeptides [D12.644.400]
    - Hypothalamic Hormones [D12.644.400.400]
      - Pituitary Hormone-Releasing Hormones [D12.644.400.400.740]
        
        Corticotropin-Releasing Hormone [D12.644.400.400.740.140]
        
        Gonadotropin-Releasing Hormone [D12.644.400.400.740.320]
        
        Buserelin [D12.644.400.400.740.320.100]
        
        Goserelin [D12.644.400.400.740.320.340]
        
        Leuprolide [D12.644.400.400.740.320.400]
        
        Nafarelin [D12.644.400.400.740.320.580]
        
        Triptorelin Pamoate [D12.644.400.400.740.320.790]
        
        Growth Hormone-Releasing Hormone [D12.644.400.400.740.860]
        
        Thyrotropin-Releasing Hormone [D12.644.400.400.740.880]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Oligopeptides [D12.644.456]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Peptide Hormones [D12.644.548]
    - Hypothalamic Hormones [D12.644.548.365]
      - Pituitary Hormone-Releasing Hormones [D12.644.548.365.740]
        
        Corticotropin-Releasing Hormone [D12.644.548.365.740.140]
        
        Gonadotropin-Releasing Hormone [D12.644.548.365.740.320]
        
        Buserelin [D12.644.548.365.740.320.100]
        
        Goserelin [D12.644.548.365.740.320.340]
        
        Leuprolide [D12.644.548.365.740.320.400]
        
        Nafarelin [D12.644.548.365.740.320.580]
        
        Triptorelin Pamoate [D12.644.548.365.740.320.790]
        
        Growth Hormone-Releasing Hormone [D12.644.548.365.740.860]
        
        Thyrotropin-Releasing Hormone [D12.644.548.365.740.880]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Nerve Tissue Proteins [D12.776.631]
    - Neuropeptides [D12.776.631.650]
      - Hypothalamic Hormones [D12.776.631.650.405]
        
        Pituitary Hormone-Releasing Hormones [D12.776.631.650.405.740]
        
        Corticotropin-Releasing Hormone [D12.776.631.650.405.740.140]
        
        Gonadotropin-Releasing Hormone [D12.776.631.650.405.740.320]
        
        Buserelin [D12.776.631.650.405.740.320.100]
        
        Goserelin [D12.776.631.650.405.740.320.340]
        
        Leuprolide [D12.776.631.650.405.740.320.400]
        
        Nafarelin [D12.776.631.650.405.740.320.580]
        
        Triptorelin Pamoate [D12.776.631.650.405.740.320.790]
        
        Growth Hormone-Releasing Hormone [D12.776.631.650.405.740.860]
        
        Thyrotropin-Releasing Hormone [D12.776.631.650.405.740.880]

Gonadotropin-Releasing Hormone Preferred

Concept UI: M0012446
Related Numbers: 51952-41-1; 52699-48-6
Scope Note: A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.
Terms: Gonadotropin-Releasing Hormone Preferred Term
Term UI T023814
Date05/17/1990
LexicalTag NON
ThesaurusID NLM (1991); LHFSH Releasing Hormone
Term UI T023824
Date12/07/1977
LexicalTag ACX
ThesaurusID UNK (19XX); LFRH
Term UI T023815
Date05/31/1983
LexicalTag ACR
ThesaurusID UNK (19XX); LH-Releasing Hormone
Term UI T023816
Date03/24/1976
LexicalTag ACX
ThesaurusID UNK (19XX); LH-FSH Releasing Hormone
Term UI T023817
Date04/02/1990
LexicalTag ACX
ThesaurusID NLM (1991); LHFSHRH
Term UI T023818
Date05/04/1982
LexicalTag ACR
ThesaurusID UNK (19XX); LHRH
Term UI T023819
Date05/17/1990
LexicalTag ACR
ThesaurusID NLM (1991); Luliberin
Term UI T023820
Date06/03/1986
LexicalTag NON
ThesaurusID UNK (19XX); Gonadorelin
Term UI T023821
Date01/01/1999
LexicalTag NON
ThesaurusID; Luteinizing Hormone-Releasing Hormone
Term UI T023822
Date04/02/1990
LexicalTag NON
ThesaurusID NLM (1991); Gn-RH
Term UI T023823
Date01/30/1981
LexicalTag ACR
ThesaurusID UNK (19XX); FSH-Releasing Hormone
Term UI T023811
Date03/30/1974
LexicalTag ACX
ThesaurusID UNK (19XX); GnRH
Term UI T023812
Date04/02/1990
LexicalTag ACR
ThesaurusID NLM (1991); Gonadoliberin
Term UI T023813
Date05/02/1990
LexicalTag NON
ThesaurusID NLM (1991); LH-RH
Term UI T023825
Date05/17/1990
LexicalTag ACR
ThesaurusID NLM (1991)

Factrel Narrower

Cystorelin Narrower

Dirigestran Narrower

Kryptocur Narrower

Gonadorelin Hydrochloride Narrower

Gonadorelin Acetate Narrower

Gonadotropin-Releasing Hormone MeSH Descriptor Data 2025